Zurletrectinib API, also known as ICP-723, is a synthetic small-molecule selective pan-tropomyosin receptor kinase (TRK) inhibitor. It targets the TRK receptor family, including TRKA, TRKB, and TRKC, which are encoded by the NTRK1, NTRK2, and NTRK3 genes.
Zurletrectinib has been investigated for its potential application in NTRK fusion-positive cancers and for activity against certain TRK mutations associated with acquired resistance to earlier-generation TRK inhibitors.
The compound has the molecular formula C₁₉H₁₉F₂N₇O₂, a molecular weight of approximately 415.4 g/mol, and CAS Number 2403703-30-8.
SDP provides sourcing and supply support for Zurletrectinib API, subject to product availability, applicable specifications, regulatory requirements, and customer requirements.
| Parameter | Details |
|---|---|
| Product Name | Zurletrectinib |
| Synonym | ICP-723 |
| CAS Number | 2403703-30-8 |
| Molecular Formula | C₁₉H₁₉F₂N₇O₂ |
| Molecular Weight | 415.4 g/mol |
| PubChem CID | 156371488 |
| ChEMBL ID | CHEMBL5095426 |
Zurletrectinib API has been investigated as a next-generation TRK inhibitor for oncology-related pharmaceutical research. Its research applications include:
Published research has investigated Zurletrectinib against several TRK resistance mutations and evaluated its brain penetration in preclinical models. These findings represent research data and should not be presented as established clinical efficacy.
Use your actual approved SDP specification/CoA for numerical limits.
| Specification | Value |
|---|---|
| Identification | IR & HPLC compliant |
| Assay | As per approved product specification |
| Related Substances | As per approved product specification |
| Loss on Drying | As per approved product specification |
| Residue on Ignition | As per approved product specification |
| Heavy Metals | Complies with applicable specification |
| Residual Solvents | Complies with applicable specification |
| pH | As per approved product specification |
Zurletrectinib API can be supplied with applicable quality and technical documentation based on the product and customer requirements. Documentation may include:
Zurletrectinib API can be supplied in packaging suitable for the required quantity and product handling conditions. Packaging, MOQ, quantity, lead time and commercial terms can be discussed according to customer requirements and product availability.
Storage conditions should follow the applicable manufacturer's specification and stability information.
Zurletrectinib is a small-molecule selective pan-TRK inhibitor, also known as ICP-723.
The CAS number is 2403703-30-8.
The molecular formula is C₁₉H₁₉F₂N₇O₂.
The molecular weight is approximately 415.4 g/mol.
Zurletrectinib targets TRKA, TRKB and TRKC.
ICP-723 is the development code for Zurletrectinib.
Bulk availability, MOQ, pricing, docum
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |