Zucapsaicin API is a synthetic cis-isomer of capsaicin and a member of the vanilloid family of compounds. It is also known by names including cis-Capsaicin and Civamide. Zucapsaicin acts on the transient receptor potential vanilloid 1 (TRPV1) channel, which plays an important role in the perception and transmission of pain.
Zucapsaicin has been investigated for topical applications associated with pain management, including osteoarthritis of the knee and neuropathic pain. It has also been studied in areas such as headache and other chronic pain conditions. PubChem identifies Zucapsaicin as a TRPV1 modulator and reports its use as a topical analgesic.
Zucapsaicin has the molecular formula C₁₈H₂₇NO₃, molecular weight 305.4 g/mol, and CAS Number 25775-90-0.
SDP provides sourcing and supply support for Zucapsaicin API, subject to product availability, applicable specifications, regulatory requirements and customer requirements.
| Parameter | Details |
|---|---|
| Product Name | Zucapsaicin |
| Synonyms | Civamide, cis-Capsaicin |
| CAS Number | 25775-90-0 |
| Molecular Formula | C₁₈H₂₇NO₃ |
| Molecular Weight | 305.4 g/mol |
| PubChem CID | 1548942 |
| ChEMBL ID | CHEMBL313971 |
| DrugBank ID | DB09120 |
| KEGG ID | D06388 |
| UNII | 15OX67P384 |
| InChIKey | YKPUWZUDDOIDPM-VURMDHGXSA-N |
The chemical identifiers above are reported by PubChem.
Zucapsaicin is the cis-isomer of capsaicin, the naturally occurring vanilloid compound responsible for the characteristic pungency of chili peppers.
As a synthetic vanilloid compound, Zucapsaicin has been studied for its interaction with TRPV1, a non-selective ion channel expressed on sensory neurons and involved in nociception and thermosensation.
Its pharmacological activity has made Zucapsaicin a subject of research involving pain signaling, neuropathic pain and musculoskeletal pain.
Zucapsaicin acts primarily through the TRPV1 receptor, also known as the capsaicin or vanilloid receptor.
TRPV1 is expressed on subsets of sensory neurons and responds to stimuli including capsaicin, noxious heat and protons. Activation of this channel is closely associated with the transmission of painful sensory signals.
As a capsaicin-related compound, Zucapsaicin interacts with TRPV1 and can influence sensory nerve signaling. Research has investigated this mechanism in relation to topical pain management and desensitization of pain-sensing pathways.
Zucapsaicin has been studied as a topical analgesic for pain conditions including osteoarthritis of the knee and neuropathic pain.
Clinical and preclinical research has evaluated Zucapsaicin for the management of neuropathic pain associated with dysfunction or injury of the peripheral or central nervous system.
Zucapsaicin has been investigated for pain associated with osteoarthritis of the knee, with research focusing on its topical analgesic activity.
Zucapsaicin has also been evaluated in research involving:
These applications should be described as research or approved-use contexts according to the applicable jurisdiction, rather than as universal therapeutic indications.
Use your actual approved Zucapsaicin specification/CoA for numerical limits.
| Parameter | Specification |
|---|---|
| Identification | IR & HPLC compliant |
| Assay | As per approved product specification |
| Related Substances | As per approved product specification |
| Loss on Drying | As per approved product specification |
| Residue on Ignition | As per approved product specification |
| Heavy Metals / Elemental Impurities | Complies with applicable specification |
| Residual Solvents | Complies with applicable specification |
| Water Content | As per approved product specification |
| Particle Size | As per applicable specification |
Do not enter assumed numerical assay or impurity limits unless they are present in your actual Zucapsaicin CoA/specification.
Zucapsaicin API supply may be supported by applicable quality and technical documentation depending on product availability and customer requirements.
Documentation may include:
Zucapsaicin API can be supplied in suitable packaging according to the required quantity, product handling requirements and customer specifications.
Customers can contact SDP regarding:
Storage conditions should follow the applicable manufacturer's specification and stability information.
Zucapsaicin is a synthetic cis-isomer of capsaicin and a TRPV1 modulator investigated for topical analgesic applications.
The CAS number of Zucapsaicin is 25775-90-0.
The molecular formula is C₁₈H₂₇NO₃.
The molecular weight is approximately 305.4 g/mol.
Zucapsaicin is also known as Civamide and cis-Capsaicin.
Zucapsaicin acts on the TRPV1 (transient receptor potential vanilloid 1) channel.
Zucapsaicin has been investigated as a topical analgesic for conditions including osteoarthritis-related pain and neuropathic pain.
Bulk availability, MOQ, pricing, documentation and lead time depend on current product availability and applicable regulatory requirements.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |