Swapnroop Drugs & Pharmaceuticals is a pharmaceutical API manufacturer and supplier of Valdecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the diaryl-substituted isoxazole class of non-steroidal anti-inflammatory drugs (NSAIDs).
Valdecoxib is identified by CAS No. 181695-72-7, molecular formula C16H14N2O3S, and molecular weight 314.36 g/mol. FDA describes Valdecoxib as 4-(5-methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide and as a white crystalline powder.
Valdecoxib selectively inhibits COX-2, an enzyme involved in prostaglandin synthesis and inflammatory responses. It was formerly marketed as Bextra for treatment of pain and inflammatory conditions.
Valdecoxib was withdrawn from the U.S. market in 2005 because of safety concerns, particularly cardiovascular and serious skin-reaction risks. Therefore, its current commercial and regulatory status should be considered when evaluating pharmaceutical applications.
FDA documentation confirms the chemical identity, formula, molecular weight, appearance and water solubility.
Valdecoxib API is associated with pharmaceutical applications involving:
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical customers requiring Valdecoxib API for qualified pharmaceutical research and development applications.
As a Valdecoxib API manufacturer and supplier in India, Swapnroop focuses on chemical identity, assay, related-substance control and other applicable quality attributes according to the relevant product specification.
Valdecoxib should be maintained in suitable, well-closed pharmaceutical packaging under controlled storage conditions and protected from contamination, excessive moisture and inappropriate environmental exposure.
Typical pharmaceutical documentation may include:
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical customers seeking professionally controlled Valdecoxib API for qualified pharmaceutical and analytical applications.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Water Content | NMT 0.5% |
| Melting Point | Approximately 157–160°C |