Swapnroop Drugs & Pharmaceuticals is a manufacturer and supplier of Treosulfan API for pharmaceutical formulation, oncology drug development and regulated pharmaceutical manufacturing applications.
Treosulfan is a synthetic alkylating agent and prodrug that undergoes non-enzymatic conversion under physiological conditions to monoepoxide and diepoxide metabolites capable of alkylating DNA. It is used as part of conditioning regimens before allogeneic hematopoietic stem cell transplantation.
Treosulfan is identified by CAS No. 299-75-2, molecular formula C6H14O8S2 and molecular weight 278.32 g/mol. It is a stereochemically defined small molecule containing two stereogenic centers. Regulatory characterization describes it as a white, non-hygroscopic crystalline solid.
Treosulfan is an alkyl sulfonate with two methanesulfonate groups. Its pharmaceutical activity results from conversion to reactive epoxide metabolites that produce DNA cross-linking.
The API is used in conditioning treatment prior to allogeneic hematopoietic stem cell transplantation, particularly in patients with hematological malignancies such as acute myeloid leukemia and myelodysplastic syndromes.
Treosulfan API is used for pharmaceutical applications involving:
Swapnroop Drugs & Pharmaceuticals provides Treosulfan API manufacturing and supply support for pharmaceutical customers requiring controlled-quality oncology APIs.
As a Treosulfan API manufacturer and supplier in India, Swapnroop focuses on consistent API quality, stereochemical control, impurity characterization, analytical documentation and reliable pharmaceutical supply.
Treosulfan should be maintained in suitable, tightly closed pharmaceutical packaging and protected from conditions that may promote degradation.
Regulatory stability information supports long-term active-substance storage under controlled conditions, while finished-product handling follows the validated pharmaceutical product specification. Treosulfan is sensitive to alkaline conditions and undergoes degradation under such conditions.
Typical pharmaceutical documentation may include:
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical customers seeking reliable Treosulfan API with controlled manufacturing, appropriate analytical characterization and professional technical support.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Melting Point | 101.5–105.0°C |