Tradipitant is a synthetic small-molecule pharmaceutical API and a selective, high-affinity neurokinin-1 (NK1) receptor antagonist. It is also known by the development names LY686017 and VLY-686. Tradipitant has the molecular formula C₂₈H₁₆ClF₆N₅O and a molecular weight of 587.9 g/mol. Its CAS Number is 622370-35-8 and its FDA GSRS UNII is NY0COC51FI.
Tradipitant is an orally bioavailable, centrally acting NK1 receptor antagonist. The FDA approved tradipitant in December 2025 for the prevention of vomiting induced by motion in adults. The approved product is marketed as NEREUS capsules.
Tradipitant selectively antagonizes the substance P/neurokinin-1 receptor (NK1R). Blocking NK1R-mediated signaling can inhibit substance-P-associated emetic signaling in the central nervous system.
According to the FDA-approved product information, tradipitant is a white to off-white crystalline powder, is practically insoluble in water, soluble in methanol, and slightly soluble in isopropyl alcohol and simulated gastric fluid.
The FDA's 2025–2026 quality review confirms that tradipitant is a new molecular entity and that the submitted CMC information was considered adequate to assure the identity, strength, purity and quality of the drug substance and drug product.
Tradipitant is an NK1 receptor antagonist used in the treatment of motion-induced vomiting in adults. The FDA-approved NEREUS formulation contains 85 mg of tradipitant per capsule.
Tradipitant has also been investigated in other clinical-development areas, including gastroparesis and inflammatory conditions; these investigational uses should not be represented as its currently approved indication.
Swapnroop Drugs & Pharmaceuticals provides API sourcing and supply support for Tradipitant for pharmaceutical manufacturing, formulation development and qualified bulk requirements.
As a Tradipitant API manufacturer and supplier in India, Swapnroop focuses on specification-based product sourcing, documentation, traceability and suitable pharmaceutical packaging. Product availability, batch specifications and technical documentation can be provided according to customer requirements.
Tradipitant API should be stored in suitable, tightly closed pharmaceutical-grade packaging under conditions established by the applicable drug-substance specification and stability data.
For reference, the FDA-approved NEREUS finished product is stored at 25°C, with permitted excursions between 15°C and 30°C. This is a finished-product storage condition and should not automatically be treated as the bulk API storage specification.
Documentation may include:
Swapnroop Drugs & Pharmaceuticals supports pharmaceutical companies seeking Tradipitant API manufacturer and supplier services in India. The supply process emphasizes product identity, specification-based quality evaluation, documentation, traceability and suitable packaging.
For bulk Tradipitant API requirements, customers can contact Swapnroop for product availability, specifications, technical documentation and commercial supply information.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |