Tosufloxacin is a synthetic fluoroquinolone antibacterial API belonging to the quinolone class. It is chemically classified as a 1,8-naphthyridine derivative and is identified by the molecular formula C₁₉H₁₅F₃N₄O₃ with a molecular weight of approximately 404.3 g/mol. PubChem and the FDA Global Substance Registration System identify Tosufloxacin as an established pharmaceutical substance, with CAS 100490-36-6 for the free base.
Tosufloxacin is classified under the WHO ATC system as J01MA22, within the fluoroquinolone antibacterial group.
Tosufloxacin is a broad-spectrum antibacterial compound developed as a fluoroquinolone antimicrobial. Its chemical structure incorporates a fluorinated aromatic ring, a 1,8-naphthyridine core, a carboxylic acid group and an aminopyrrolidine substituent. The compound is associated with inhibition of bacterial DNA gyrase and topoisomerase IV, mechanisms characteristic of fluoroquinolone antibacterial activity.
Tosufloxacin is commonly encountered commercially in its tosilate/tosylate form, particularly Tosufloxacin Tosilate Hydrate, while Tosufloxacin itself represents the active moiety/free-base substance. The Japanese Pharmacopoeia identifies Tosufloxacin Tosilate Hydrate as a pharmaceutical substance with the formula-based molecular mass of 594.56 g/mol for the monohydrate form.
| Property | Details |
|---|---|
| Product Name | Tosufloxacin |
| API Type | Synthetic small-molecule API |
| Therapeutic Class | Fluoroquinolone antibacterial |
| CAS Number | 100490-36-6 |
| Molecular Formula | C₁₉H₁₅F₃N₄O₃ |
| Molecular Weight | 404.3 g/mol |
| UNII | GHJ553KQPS |
| ATC Code | J01MA22 |
| Appearance | White to off-white/pale yellow powder* |
| Active Moiety | Tosufloxacin |
| Common Pharmaceutical Salt | Tosufloxacin Tosilate/Tosylate Hydrate |
| Storage | Controlled pharmaceutical storage conditions |
*Appearance is based on publicly available reference material rather than a universal pharmacopoeial free-base specification.
Tosufloxacin is classified as a fluoroquinolone antibacterial agent and is associated with antibacterial treatment applications. Its WHO ATC classification is J01MA22, and WHO's ATC/DDD index lists an oral defined daily dose of 0.45 g.
Tosufloxacin is also used in pharmaceutical development and manufacturing principally through its tosilate/tosylate salt, including Tosufloxacin Tosilate Hydrate. Japanese pharmaceutical information identifies this form as a new-quinolone oral antibacterial preparation.
Swapnroop Drugs & Pharmaceuticals offers pharmaceutical API sourcing and supply solutions for Tosufloxacin for customers requiring quality-focused active pharmaceutical ingredients. Tosufloxacin can be supplied for pharmaceutical manufacturing, formulation development, research and other qualified applications, subject to applicable specifications and documentation.
As an API manufacturer and supplier in India, Swapnroop Drugs & Pharmaceuticals focuses on controlled sourcing, analytical documentation, appropriate packaging and batch-level quality requirements. Customers can request product specifications, Certificate of Analysis (CoA), technical documentation and other relevant quality documents according to their intended application.
Tosufloxacin should be stored in appropriately sealed pharmaceutical-grade packaging under conditions established by the applicable product specification and stability data. Protection from excessive moisture, heat and unsuitable light exposure should be maintained.
Packaging configurations can be selected according to customer requirements, batch size and intended pharmaceutical application.
Typical documentation available upon request may include:
Swapnroop Drugs & Pharmaceuticals provides a professional API sourcing and supply platform for pharmaceutical manufacturers and formulation companies seeking Tosufloxacin API in India and international markets. The company emphasizes product traceability, specification-based quality assessment, suitable packaging and documentation support.
For pharmaceutical companies looking for a Tosufloxacin API manufacturer and supplier in India, Swapnroop can support bulk API requirements according to agreed technical and commercial specifications.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.5% |
| Loss on Drying | 3.0–4.5% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |