Swapnroop Drugs & Pharmaceuticals is a pharmaceutical Tolmetin API manufacturer and supplier in India, supporting qualified pharmaceutical companies, formulation manufacturers, research organizations, and bulk procurement requirements.
Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) belonging to the pyrrole acetic acid class. It is chemically identified as 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid and has the molecular formula C₁₅H₁₅NO₃ with a molecular weight of 257.28 g/mol. The CAS number of the free acid is 26171-23-3.
Tolmetin is the parent active moiety of tolmetin sodium, which has been used as a nonselective NSAID with analgesic, anti-inflammatory, and antipyretic activity. PubChem identifies tolmetin as a cyclooxygenase/prostaglandin-endoperoxide synthase inhibitor.
Tolmetin is a monocarboxylic acid and pyrrole derivative containing an aromatic ketone group. It is commonly encountered pharmaceutically through its sodium salt, particularly tolmetin sodium dihydrate (CAS 64490-92-2).
The free acid has the following chemical profile:
Tolmetin is reported as a solid, with descriptions including crystals from acetonitrile and off-white to pale-yellow material. PubChem reports a melting point of approximately 156°C, with older reference data describing decomposition around 155–157°C.
Its reported aqueous solubility is approximately 222 mg/L, while its acidic pKa is around 3.5. These values are useful chemical-reference data and should not be interpreted as pharmaceutical release specifications.
Tolmetin belongs to the NSAID class and acts primarily through inhibition of prostaglandin synthesis. The pharmaceutical active moiety has analgesic, anti-inflammatory and antipyretic properties.
Tolmetin is particularly associated with its sodium salt form, including tolmetin sodium dihydrate, which has been used in oral pharmaceutical dosage forms.
Swapnroop supports the supply of Tolmetin API for qualified pharmaceutical and formulation requirements.
API supply can be supported with applicable product specifications and pharmaceutical documentation, depending on the required grade, batch and regulatory market.
For customers requiring the sodium form, Tolmetin Sodium Dihydrate is a distinct material with CAS 64490-92-2, molecular formula C₁₅H₁₈NNaO₅, and molecular weight 315.30 g/mol. It should not be confused with the free acid Tolmetin listed on this page.
Tolmetin API should be stored in a suitable pharmaceutical-grade, tightly closed container under appropriate controlled conditions. Packaging should protect the material from excessive moisture, contamination and environmental exposure.
Storage and packaging conditions should ultimately follow the applicable approved product specification and stability information.
Depending on the supply arrangement, documentation can include:
Swapnroop Drugs & Pharmaceuticals provides Tolmetin API for qualified pharmaceutical, formulation and bulk procurement requirements.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| pH (1% Solution) | 3.5 |
| Melting Point | Approximately 156°C |