Swapnroop Drugs & Pharmaceuticals is a pharmaceutical API manufacturer and supplier of Tolazoline API in India, supporting pharmaceutical, veterinary, research and bulk active ingredient requirements.
Tolazoline is a synthetic imidazoline derivative with vasodilator and alpha-adrenergic antagonist activity. It is chemically identified as 2-benzyl-4,5-dihydro-1H-imidazole and has the molecular formula C₁₀H₁₂N₂ with a molecular weight of 160.22 g/mol. The CAS Number is 59-98-3.
Tolazoline is the free-base active moiety related to Tolazoline Hydrochloride (CAS 59-97-2). FDA GSRS and PubChem distinguish Tolazoline from its hydrochloride salt.
Tolazoline belongs to the imidazoline derivative class and has pharmacological activity as a vasodilator and alpha-adrenergic antagonist. It has historically been used in applications involving peripheral vascular effects and veterinary medicine.
Tolazoline is described as a white to off-white crystalline powder. Published pharmaceutical references report that it is freely soluble in water and alcohol, with a melting point around 174°C.
| Parameter | Details |
|---|---|
| Product Name | Tolazoline |
| CAS Number | 59-98-3 |
| UNII | CHH9H12AQ3 |
| Molecular Formula | C₁₀H₁₂N₂ |
| Molecular Weight | 160.22 g/mol |
| Chemical Name | 2-Benzyl-4,5-dihydro-1H-imidazole |
| IUPAC Name | 2-Benzyl-4,5-dihydro-1H-imidazole |
| API Category | Imidazoline Derivative / Vasodilator |
| Parent Salt | Tolazoline Hydrochloride |
| Parent Salt CAS | 59-97-2 |
| Physical Form | White to off-white crystalline powder |
| Optical Activity | Achiral |
PubChem identifies CAS 59-98-3, formula C₁₀H₁₂N₂ and molecular weight 160.22 g/mol for Tolazoline.
Tolazoline exhibits alpha-adrenergic antagonist activity and produces vasodilation through effects on vascular adrenergic signaling. It may also interact with other receptor systems, including histaminergic and cholinergic pathways.
Tolazoline has been associated with:
Tolazoline has also been used in veterinary medicine to reverse the effects of xylazine-induced sedation, particularly in livestock and other veterinary applications.
Swapnroop Drugs & Pharmaceuticals supplies Tolazoline API for qualified pharmaceutical, veterinary, research and bulk procurement requirements.
As a Tolazoline API supplier in India, Swapnroop supports API sourcing, formulation development, analytical requirements and international supply, subject to applicable product specifications and regulatory requirements.
Tolazoline API can be supplied for:
Tolazoline free base should not be assigned the USP assay specification of Tolazoline Hydrochloride. The USP monograph available publicly is specifically for Tolazoline Hydrochloride (CAS 59-97-2) and specifies 98.0–101.0% of the hydrochloride salt.
Therefore, for a Tolazoline free-base CMS page, supplier/manufacturer-specific specifications should be used unless a current authoritative monograph for the free base is available.
Published references describe Tolazoline as a white to off-white crystalline powder, with a melting point around 174°C and water solubility of approximately 373 mg/L at 25°C.
Tolazoline API should be stored in suitable, tightly closed packaging that protects the material from contamination and inappropriate environmental exposure.
Final packaging and storage conditions should follow the applicable manufacturer specification, stability data and customer requirements.
Documentation may include:
Tolazoline is a well-characterized imidazoline derivative and vasodilator with established chemical identity. Swapnroop Drugs & Pharmaceuticals supports organizations seeking Tolazoline API in India for qualified pharmaceutical, veterinary, research and bulk procurement requirements.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0–101.0% on dried basis |
| Loss on Drying | NMT 0.2% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| Total Impurities | NMT 1.0% |
| Melting Point | Approx. 174°C |