Swapnroop Drugs & Pharmaceuticals is a pharmaceutical API manufacturer and supplier of Tobramycin Sulfate API in India, supporting pharmaceutical formulation, generic drug manufacturing, bulk API procurement and export requirements.
Tobramycin Sulfate is the sulfate salt of tobramycin, an aminoglycoside antibacterial agent. Tobramycin acts primarily by binding to the bacterial 30S ribosomal subunit, interfering with protein synthesis and producing antibacterial activity.
Tobramycin Sulfate is identified by CAS 49842-07-1 in current PubChem records, while 79645-27-5 is also encountered as a legacy/deprecated CAS identifier.
Tobramycin Sulfate belongs to the aminoglycoside antibiotic class and is used in pharmaceutical products intended for the treatment of susceptible bacterial infections.
The sulfate salt is commonly represented as:
(C₁₈H₃₇N₅O₉)₂ · 5H₂SO₄
with a molecular weight of approximately 1425.4 g/mol.
The API is described as a white to almost white powder and is water soluble. Tobramycin Sulfate is hygroscopic and requires appropriate moisture-protective packaging.
| Parameter | Details |
|---|---|
| Product Name | Tobramycin Sulfate |
| CAS Number | 49842-07-1 |
| Legacy/Alternate CAS | 79645-27-5 |
| Molecular Formula | (C₁₈H₃₇N₅O₉)₂ · 5H₂SO₄ |
| Molecular Weight | 1425.4 g/mol |
| Parent API | Tobramycin |
| Parent CAS | 32986-56-4 |
| API Category | Aminoglycoside Antibiotic |
| Therapeutic Category | Antibacterial |
| Physical Form | White to almost white powder |
| Solubility | Soluble in water; difficult to dissolve in ethanol; practically insoluble in chloroform and ether |
PubChem reports the molecular formula C₃₆H₈₄N₁₀O₃₈S₅, molecular weight 1425.4 g/mol, and CAS 49842-07-1 for Tobramycin Sulfate.
Tobramycin is an aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit. This interferes with initiation and accuracy of bacterial protein synthesis, including misreading of mRNA, ultimately contributing to bacterial cell death.
Tobramycin Sulfate API is used in the development and manufacture of pharmaceutical products for susceptible bacterial infections, particularly infections involving susceptible Gram-negative organisms.
It is used in pharmaceutical preparations including:
Tobramycin sulfate is described in FDA labeling as a water-soluble aminoglycoside antibiotic derived from Streptomyces tenebrarius.
Swapnroop Drugs & Pharmaceuticals supplies Tobramycin Sulfate API for pharmaceutical manufacturers and formulation companies requiring an aminoglycoside antibiotic API.
As a Tobramycin Sulfate API supplier in India, Swapnroop supports bulk procurement, formulation manufacturing, development requirements and international pharmaceutical supply.
Supply can be arranged according to agreed specifications, quantity, packaging and applicable regulatory documentation.
Tobramycin Sulfate API can be supplied for:
Tobramycin Sulfate has a USP monograph with a potency specification of 634–739 µg/mg of tobramycin, determined by an HPLC-based derivatization assay. The USP specification also includes pH 6.0–8.0 at 40 mg/mL and residue on ignition NMT 1.0%. The current USP revision specifies water NMT 7.0%.
Where Tobramycin Sulfate is intended for injectable manufacture, USP additionally addresses bacterial endotoxins and sterility requirements according to the applicable labeling/use.
Tobramycin Sulfate should be protected from moisture because the material is hygroscopic. The USP specifies preservation in tight containers.
Storage and packaging should follow the applicable approved specification, stability data and customer requirements.
Depending on the supply requirement, documentation may include:
Tobramycin Sulfate is an established aminoglycoside antibacterial API with defined pharmacopoeial potency and quality requirements. Swapnroop Drugs & Pharmaceuticals supports pharmaceutical companies seeking Tobramycin Sulfate API in India for formulation development, commercial manufacturing, bulk procurement and export requirements.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Residue on Ignition | NMT 1.0% |
| pH (1% Solution) | 6.0–8.0 |
| Individual Impurity | NMT 1.0% |
| Water Content | NMT 7.0% |