Tizanidine SR Pellets Manufacturer India

Tizanidineb SR Pellets (CAS No: 64461-82-1) — Sustained Release Multiparticulates

Tizanidine HCl SR Pellets are sustained-release pharmaceutical pellets manufactured from Tizanidine Hydrochloride (C₉H₈ClN₅S·HCl, MW ≈290.2), a centrally-acting α2-adrenergic agonist used to manage spasticity from conditions such as multiple sclerosis and spinal cord injury. Swapnroop Drugs and Pharmaceuticals manufactures Tizanidine HCl SR Pellets at its WHO-GMP certified Aurangabad, Maharashtra facility for pharmaceutical formulators across India and export markets.

Formulation Approach
Tizanidine HCl is highly water-soluble (>20 mg/mL), which is a relevant formulation consideration when designing the rate-controlling functional coat needed to achieve a genuine extended-release profile rather than rapid dose-dumping; SR pellet systems for this molecule are typically built by drug-layering followed by a calibrated polymer coat.

Key Features

• Sustained-release multiparticulate formulation for a highly water-soluble drug substance
• Centrally-acting α2-adrenergic agonist muscle relaxant
• Suitable for hard-gelatin capsule filling and multiparticulate tablet compression
• WHO-GMP manufactured with full batch documentation

Applications

• Spasticity management (multiple sclerosis, spinal cord injury, and related conditions)
• Extended-duration muscle-relaxant capsule/tablet formulations
• Generic ANDA/CTD dossier programs requiring dissolution-matched SR profiles

Why Choose Swapnroop for Tizanidine SR Pellets?

• WHO-GMP certified facility with drug-layering and functional-coating expertise, including for highly water-soluble actives
• Full CoA, MSDS, DMF-grade documentation for regulated-market submissions

FAQs

• Why is sustained release important for Tizanidine? Tizanidine's immediate-release form has a short duration of action and pronounced sedative side effects at peak plasma levels; an SR profile is used to smooth the plasma curve for better tolerability.
• Is Tizanidine HCl water-soluble? Yes — it is soluble in water at concentrations greater than 20 mg/mL, which is an important consideration for coating-system design.

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