Ticarcillin is a semisynthetic penicillin-class antibacterial active pharmaceutical ingredient with broad-spectrum bactericidal activity. In pharmaceutical applications, Ticarcillin is commonly used in its disodium salt form, Ticarcillin Disodium. Ticarcillin Disodium has the molecular formula C₁₅H₁₄N₂Na₂O₆S₂, molecular weight 428.4 g/mol, and CAS No. 29457-07-6.
Ticarcillin belongs to the beta-lactam antibiotic class and acts by interfering with bacterial cell-wall synthesis. It is structurally related to carbenicillin and has activity against a range of Gram-positive and Gram-negative bacteria.
For this product page, the pharmaceutical API is treated as Ticarcillin Disodium, rather than the free Ticarcillin acid. The free acid has a different CAS number (34787-01-4) and molecular weight (384.4 g/mol), so its specifications should not be mixed with Ticarcillin Disodium.
Swapnroop Drugs & Pharmaceuticals focuses on quality-oriented Ticarcillin API manufacturing in India for authorized pharmaceutical applications and formulation requirements.
Ticarcillin is a penicillin derivative containing a beta-lactam ring and a thiophene-containing side chain. Its disodium salt improves the pharmaceutical handling characteristics of the active ingredient and is the form used in established pharmaceutical products.
PubChem identifies Ticarcillin Disodium as the disodium salt of Ticarcillin and lists its molecular formula, molecular weight and CAS number.
Ticarcillin Disodium is the disodium salt of Ticarcillin, a semisynthetic penicillin antibiotic. It contains a beta-lactam structure that is essential for its antibacterial activity.
Chemical Formula: C₁₅H₁₄N₂Na₂O₆S₂
Molecular Weight: 428.4 g/mol
CAS No.: 29457-07-6
PubChem CID: 470375
Ticarcillin inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins and interfering with the transpeptidation step required for peptidoglycan cross-linking. This ultimately leads to bacterial cell-wall instability and cell lysis.
Ticarcillin is a beta-lactam antibacterial agent. Its beta-lactam structure enables it to interact with bacterial penicillin-binding proteins.
The resulting inhibition of peptidoglycan cross-linking interferes with the final stages of bacterial cell-wall synthesis. The weakened bacterial cell wall can subsequently lead to cell lysis.
Ticarcillin is therefore classified as a bactericidal penicillin antibiotic.
Ticarcillin Disodium API is associated with pharmaceutical formulations for antibacterial treatment and development.
Potential pharmaceutical applications include:
Ticarcillin has historically been used against susceptible Gram-positive and Gram-negative aerobic and anaerobic bacteria. Its actual therapeutic use should follow the approved product labeling and applicable regulatory requirements.
Ticarcillin Disodium requires product-specific analytical testing because it is a beta-lactam antibiotic and moisture-sensitive pharmaceutical substance.
Typical quality-control testing includes:
The current USP 2025 specification available in the referenced monograph gives a ticarcillin potency of NLT 800 µg/mg on an anhydrous basis, specific rotation of +172° to +187°, pH 6.0–8.0, and water NMT 6.0%.
Swapnroop Drugs & Pharmaceuticals focuses on quality-oriented pharmaceutical API manufacturing for authorized pharmaceutical customers.
As a Ticarcillin API Manufacturer in India, Swapnroop focuses on:
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| pH (1% Solution) | 6.0 – 8.0 |
| Water Content | NMT 6.0% |
| Specific Rotation | +172° to +187° |