Thioridazine API is a synthetic phenothiazine derivative belonging to the first-generation antipsychotic class. It is chemically identified as 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine. Thioridazine has the molecular formula C₂₁H₂₆N₂S₂, molecular weight 370.575 g/mol, and CAS No. 50-52-2.
Thioridazine has historically been used as an antipsychotic pharmaceutical ingredient. It acts primarily through effects on dopaminergic and other neurotransmitter receptor systems. PubChem classifies it as a phenothiazine and first-generation antipsychotic.
Important: This page refers to Thioridazine free base (CAS 50-52-2), not Thioridazine Hydrochloride (CAS 130-61-0). The two forms have different molecular weights and specifications. The USP monograph for Thioridazine confirms an assay of 99.0–101.0% on the dried basis.
Thioridazine belongs to the phenothiazine class of pharmaceutical active ingredients. It is a sulfur-containing heterocyclic compound containing a phenothiazine nucleus, methylsulfanyl group and N-methylpiperidinyl ethyl side chain.
Thioridazine is a phenothiazine derivative with the molecular formula C₂₁H₂₆N₂S₂. NIST reports a molecular weight of 370.575 g/mol and CAS No. 50-52-2.
The compound is structurally related to other phenothiazine APIs but has a distinctive methylsulfanyl substituent and methylpiperidinyl side chain.
Thioridazine is highly lipophilic and has very low water solubility; published pharmaceutical references describe it as soluble in organic solvents and practically insoluble in water.
Thioridazine is a phenothiazine antipsychotic that interacts with several neurotransmitter receptor systems. Its pharmacological activity includes antagonism of dopamine receptors, with additional activity at serotonergic, histamine and adrenergic receptors.
Thioridazine has historically been associated with pharmaceutical formulations for:
Regulatory note: Thioridazine has significant historical safety restrictions because of its association with cardiac arrhythmias and QT prolongation. PubChem notes that it was withdrawn worldwide in 2005. Therefore, any commercial use of the API should be handled according to the applicable regulatory requirements and authorized pharmaceutical applications.
| Parameter | Details |
|---|---|
| Product Name | Thioridazine |
| API Type | Pharmaceutical API |
| CAS No. | 50-52-2 |
| Molecular Formula | C₂₁H₂₆N₂S₂ |
| Molecular Weight | 370.575 g/mol |
| PubChem CID | 5452 |
| Chemical Class | Phenothiazine derivative |
| Therapeutic Category | Antipsychotic |
| IUPAC Name | 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine |
| Physical Form | As per approved specification |
| Manufacturer | Swapnroop Drugs & Pharmaceuticals |
Depending on customer and regulatory requirements, documentation may include:
Swapnroop Drugs & Pharmaceuticals focuses on quality-oriented pharmaceutical API manufacturing and supports authorized pharmaceutical customers requiring active ingredients for formulation and development applications.
As a Thioridazine API Manufacturer in India, Swapnroop focuses on:
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 99.0% – 101.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 0.5% |