Thiabendazole API is a synthetic benzimidazole derivative with established anthelmintic and antifungal properties. It is chemically identified as 4-(1H-benzimidazol-2-yl)-1,3-thiazole and belongs to the benzimidazole class of pharmaceutical active ingredients. Thiabendazole has the molecular formula C₁₀H₇N₃S and a molecular weight of 201.25 g/mol. Its CAS number is 148-79-8.
Thiabendazole has applications associated with antiparasitic and antifungal activity and has been used in pharmaceutical and veterinary-related formulations. PubChem identifies Thiabendazole as an anthelmintic and antifungal compound.
Swapnroop Drugs & Pharmaceuticals provides quality-focused Thiabendazole API manufacturing in India, supporting pharmaceutical formulation, development and other authorized industry requirements.
Thiabendazole is a benzimidazole compound containing a thiazole substituent. Its chemical structure provides the basis for its pharmacological activity against susceptible parasites and fungi.
The API is commonly identified by the following chemical characteristics:
These identity details are supported by PubChem and other chemical reference databases.
Thiabendazole is a heterocyclic benzimidazole derivative with the molecular formula C₁₀H₇N₃S. It is described as a white or cream-colored powder and is associated with anthelmintic and antifungal activity.
The compound's chemical structure consists of a benzimidazole nucleus linked to a thiazole ring. This structural arrangement is characteristic of Thiabendazole and distinguishes it from other benzimidazole APIs.
As a benzimidazole-class anthelmintic, Thiabendazole acts primarily by interfering with microtubule-related processes in susceptible parasites. This disruption affects cellular functions necessary for parasite survival.
Its antifungal activity is associated with interference with fungal cellular processes, supporting its use in antifungal applications.
Thiabendazole API is associated with:
The compound is classified in PubChem records with anthelmintic and antifungal activity.
Quality control of Thiabendazole API involves testing to confirm identity, purity, assay and physicochemical characteristics.
Typical analytical controls include:
For pharmaceutical API production, acceptance criteria should follow the applicable current approved specification or pharmacopoeial requirements.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 101.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 0.5% |
| Melting Point | 296–303°C (decomposition) |