Tetrandrine API is a naturally occurring bisbenzylisoquinoline alkaloid associated with the plant Stephania tetrandra. It belongs to the isoquinoline alkaloid class and has been investigated for calcium-channel modulation, anti-inflammatory, immunomodulatory and other pharmacological activities.
Tetrandrine is chemically distinct from Tetrandrine Hydrochloride and Tetrandrine Dihydrochloride. This page refers specifically to the free-base Tetrandrine API, CAS 518-34-3. The hydrochloride salt has a different molecular formula and molecular weight and should not be mixed with the free-base specification.
| Parameter | Details |
|---|---|
| Product Name | Tetrandrine |
| API Category | Natural Alkaloid API |
| Chemical Class | Bisbenzylisoquinoline Alkaloid |
| CAS No. | 518-34-3 |
| Molecular Formula | C₃₈H₄₂N₂O₆ |
| Molecular Weight | 622.7 g/mol |
| PubChem CID | 73078 |
| Synonyms | D-Tetrandrine, (+)-Tetrandrine, Tetrandrin |
| Source | Stephania tetrandra and related botanical sources |
| Therapeutic/Research Category | Calcium-channel modulator / anti-inflammatory and immunomodulatory research API |
PubChem identifies Tetrandrine as C₃₈H₄₂N₂O₆ with a molecular weight of 622.7 g/mol and CAS 518-34-3.
Tetrandrine has been investigated in pharmaceutical and biomedical research for several biological activities, including:
Tetrandrine has been described as a non-selective calcium-channel inhibitor and has been studied for immunosuppressive, antiproliferative and free-radical-scavenging effects.
Tetrandrine is a bisbenzylisoquinoline alkaloid that has been reported to interfere with calcium-channel activity. Changes in intracellular calcium signaling can influence processes including cellular proliferation, inflammatory signaling and smooth-muscle activity.
Because Tetrandrine has multiple reported pharmacological activities, its mechanism can vary depending on the biological system and research model.
For pharmaceutical-grade Tetrandrine API, quality control should include appropriate analytical testing for identity, assay, purity and physicochemical characteristics.
Typical analytical testing may include:
Numerical acceptance criteria should be taken from the applicable approved specification or current validated product specification rather than transferred from another Tetrandrine salt.
Important specification note: I could verify the exact identity values for Tetrandrine, but I could not verify a current authoritative public pharmacopoeial monograph providing universal numerical assay and impurity limits specifically for the free-base Tetrandrine API. Therefore, I recommend not inserting an invented assay such as 98.0–102.0% or 99.0% minimum into your CMS. PubChem confirms the product-specific identity data.
Swapnroop Drugs & Pharmaceuticals provides quality-focused pharmaceutical API manufacturing capabilities for customers requiring Tetrandrine for pharmaceutical, formulation and research applications.
As a Tetrandrine API Manufacturer in India, Swapnroop focuses on:
Tetrandrine API should be packed in suitable pharmaceutical-grade packaging to protect the material from moisture, light and environmental contamination.
Store in a well-closed container under validated storage conditions, protected from excessive moisture, heat and direct light.
Documentation can include:
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |