Tamsulosin Hydrochloride is a selective alpha-1 adrenergic receptor antagonist used primarily in pharmaceutical formulations for the management of symptoms associated with benign prostatic hyperplasia (BPH). It preferentially acts on α1A-adrenoceptors in the prostate and bladder neck, helping relax smooth muscle and improve urinary flow.
Tamsulosin Hydrochloride is a small-molecule pharmaceutical API with the molecular formula C20H29ClN2O5S, molecular weight 444.97 g/mol, and CAS Number 106463-17-6.
Swapnroop offers Tamsulosin Hydrochloride API for pharmaceutical formulation, research and development, and bulk manufacturing requirements, subject to applicable quality specifications and documentation.
Tamsulosin Hydrochloride is the hydrochloride salt of tamsulosin and belongs to the class of selective α1-adrenergic receptor antagonists. Its preferential affinity for α1A receptors makes it an important API for pharmaceutical products intended for lower urinary tract symptoms associated with BPH.
Tamsulosin Hydrochloride is commonly incorporated into oral modified-release pharmaceutical formulations.
Tamsulosin Hydrochloride is chemically identified as 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride.
The API contains a defined R-stereochemical configuration, making stereochemical purity an important quality attribute.
| Parameter | Tamsulosin Hydrochloride |
|---|---|
| Chemical Name | Tamsulosin Hydrochloride |
| CAS Number | 106463-17-6 |
| Molecular Formula | C20H29ClN2O5S |
| Molecular Weight | 444.97 g/mol |
| Chemical Class | Sulfonamide derivative |
| Pharmacological Class | Selective α1-Adrenoceptor Antagonist |
| Therapeutic Area | Urology |
| Primary Application | Benign Prostatic Hyperplasia |
| Physical Form | White or almost white powder |
| Salt Form | Hydrochloride |
Tamsulosin Hydrochloride API is primarily used for the development and manufacture of pharmaceutical products for:
Tamsulosin's selective α1-adrenoceptor activity helps relax smooth muscle in the prostate and bladder neck.
Tamsulosin Hydrochloride requires appropriate analytical testing for identity, assay, related substances and stereochemical purity.
Typical quality-control testing includes:
For USP 2025, the assay specification is 98.0%–102.0%. BP/Ph. Eur. specifications use 98.5%–101.0% on the dried substance.
Swapnroop provides pharmaceutical API solutions for customers requiring Tamsulosin Hydrochloride for formulation development and pharmaceutical manufacturing.
Our supply approach focuses on:
Tamsulosin Hydrochloride can be supplied according to applicable pharmacopoeial and customer-specific specifications.
Tamsulosin Hydrochloride should be packaged in suitable pharmaceutical-grade, tight or well-closed containers that protect the API from moisture, contamination and environmental exposure.
Store under controlled conditions according to the applicable product specification and manufacturer's stability data.
Documentation may include:
Swapnroop supports pharmaceutical manufacturers and formulation developers with quality-focused API solutions. Tamsulosin Hydrochloride is supplied for pharmaceutical applications requiring control of assay, related substances and stereochemical purity.
For Tamsulosin Hydrochloride API bulk requirements, technical specifications, documentation and commercial enquiries, contact Swapnroop.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.10% |
| Heavy Metals | NMT 20 ppm |
| Water Content | NMT 0.5% |
| Melting Point | About 230° |