Tafenoquine is a long-acting 8-aminoquinoline antimalarial active pharmaceutical ingredient (API). It is associated with the treatment and prevention of malaria, particularly applications involving Plasmodium vivax and prevention of relapse. Tafenoquine has the chemical formula C24H28F3N3O3, molecular weight 463.5 g/mol, and CAS Number 106635-80-7.
Swapnroop provides Tafenoquine API for pharmaceutical development, formulation manufacturing and bulk API requirements, subject to applicable specifications and documentation.
Tafenoquine belongs to the 8-aminoquinoline class of antimalarial compounds and is structurally related to primaquine. Its long-acting profile makes it an important compound for pharmaceutical applications involving malaria prophylaxis and prevention of P. vivax relapse.
The API is chemically identified as:
4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine.
Tafenoquine should be distinguished from its salt forms. For example, Tafenoquine Succinate has CAS Number 106635-81-8 and a different molecular formula and molecular weight.
Tafenoquine is an aminoquinoline derivative containing a quinoline nucleus, methoxy groups, a methyl substituent, a trifluoromethyl-substituted phenoxy group and an aminoalkyl side chain.
Key chemical identifiers include:
Tafenoquine is used in pharmaceutical applications associated with:
Its pharmacological use is associated with both blood-stage and liver-stage activity relevant to malaria, including the stages involved in P. vivax relapse.
Tafenoquine API should undergo appropriate analytical testing to establish identity, purity and compliance with the applicable product specification.
Typical analytical parameters may include:
The acceptance criteria should be based on the approved Tafenoquine API specification, applicable pharmacopoeial requirements, regulatory requirements or customer-specific specifications rather than generic limits.
Swapnroop supports pharmaceutical API requirements for domestic and international customers. Tafenoquine API can be supplied for pharmaceutical manufacturing, research and development and formulation-related applications according to agreed specifications.
Our API supply approach focuses on:
Contact Swapnroop for current Tafenoquine API specifications, availability, packaging and technical documentation.
Tafenoquine API should be packed in suitable pharmaceutical-grade containers that protect the material against contamination, moisture and environmental exposure.
Storage: Store in a tightly closed container under controlled conditions according to the applicable product specification, safety documentation and stability data.
Specific storage conditions should always be confirmed against the current manufacturer's specification and CoA.
Depending on the order and applicable regulatory requirements, documentation may include:
Swapnroop provides pharmaceutical API solutions for formulation development, pharmaceutical manufacturing and bulk requirements. Tafenoquine API is offered as an 8-aminoquinoline antimalarial API for customers requiring a reliable pharmaceutical raw material source.
For Tafenoquine API bulk requirements, technical specifications, documentation and commercial enquiries, contact Swapnroop.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |