Suprofen is a non-steroidal anti-inflammatory drug (NSAID) active pharmaceutical ingredient (API) belonging to the arylpropionic acid class of anti-inflammatory compounds.
Suprofen has CAS Number 40828-46-4, molecular formula C₁₄H₁₂O₃S and molecular weight 260.31 g/mol. Its chemical name is 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid. It is also known as p-2-Thenoylhydratropic acid. (pubchem.ncbi.nlm.nih.gov)
Suprofen contains a propionic acid moiety attached to a substituted phenyl group containing a thiophene carbonyl structure.
The API is generally characterized as a crystalline solid and can be identified using infrared and ultraviolet absorption techniques. Its pharmaceutical quality can be evaluated through HPLC assay, impurity testing, moisture determination and physical-property testing.
Suprofen has a molecular weight of 260.31 g/mol and is recognized as a non-narcotic analgesic and prostaglandin biosynthesis inhibitor. (ebi.ac.uk)
Suprofen is associated with anti-inflammatory and analgesic pharmaceutical applications. Its pharmacological activity is related to inhibition of prostaglandin biosynthesis through cyclooxygenase pathway inhibition.
The compound has been classified as a non-steroidal anti-inflammatory drug and non-narcotic analgesic. (ebi.ac.uk)
Suprofen has also been used in ophthalmic pharmaceutical applications, particularly in formulations where its anti-inflammatory activity is required.
Suprofen API can be evaluated using pharmacopoeial identity, HPLC assay, moisture, inorganic-residue, heavy-metal and impurity testing.
The USP monograph specifies Suprofen at 98.0–102.0% calculated on the dried basis. It also specifies loss on drying of not more than 0.5%, residue on ignition of not more than 0.2%, and heavy metals at not more than 0.002% (20 ppm). (drugfuture.com)
Typical analytical controls may include:
The USP HPLC assay uses a phosphate buffer/methanol mobile phase and UV detection as part of the chromatographic procedure. (drugfuture.com)
Swapnroop Drugs and Pharmaceuticals provides pharmaceutical API manufacturing capabilities for Suprofen with quality-focused analytical evaluation and documentation.
Suprofen API can be handled according to applicable pharmacopoeial requirements and agreed customer specifications. Quality evaluation can cover identity, HPLC assay, impurities, moisture, inorganic residue and physical characteristics.
For pharmaceutical companies requiring Suprofen API from an India-based manufacturer, specification alignment, batch consistency, analytical testing and appropriate documentation are important considerations.
Suprofen API should be stored in suitable, tightly closed pharmaceutical packaging that protects the material from contamination, moisture and excessive environmental exposure.
The USP monograph specifies preservation in well-closed containers. (drugfuture.com)
Recommended handling includes:
Depending on customer and regulatory requirements, documentation may include:
Swapnroop Drugs and Pharmaceuticals focuses on pharmaceutical API manufacturing with quality systems, analytical evaluation and documentation intended to support pharmaceutical applications.
Suprofen API is handled according to defined quality requirements with attention to identity, assay, impurities, physical characteristics and batch-to-batch consistency.
Customers can discuss Suprofen API requirements, applicable specifications, packaging and documentation with Swapnroop Drugs and Pharmaceuticals.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |
| Melting Point | 118–125°C |