Sulfamethoxypyridazine is a long-acting sulfonamide antibacterial active pharmaceutical ingredient (API). It belongs to the sulfonamide class and contains a pyridazine ring with a methoxy substituent and a sulfanilamide group.
Sulfamethoxypyridazine has the CAS Number 80-35-3, molecular formula C₁₁H₁₂N₄O₃S and molecular weight 280.30 g/mol. It is also known by names including Sulphamethoxypyridazine and Sulfapyridazine. NIST and PubChem confirm its chemical identity and molecular characteristics.
Sulfamethoxypyridazine is chemically identified as 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide. The compound is generally described as a white to light yellow or light orange crystalline powder or crystals.
It belongs to the sulfonamide antibiotic class and functions as an inhibitor of bacterial dihydropteroate synthase, an enzyme involved in the bacterial folate biosynthesis pathway.
Sulfamethoxypyridazine has a molecular weight of 280.30 g/mol and is a solid at room temperature. Analytical characterization can include infrared spectroscopy, chromatographic purity testing and other appropriate structural identification techniques.
Sulfamethoxypyridazine is associated with antibacterial pharmaceutical applications as a sulfonamide antimicrobial.
Its antibacterial activity is related to interference with bacterial folate synthesis. As a structural analogue of para-aminobenzoic acid (PABA), sulfonamides inhibit dihydropteroate synthase and thereby interfere with the formation of folate intermediates required for bacterial growth.
Sulfamethoxypyridazine has historically been characterized as a long-acting sulfonamide antibiotic.
Sulfamethoxypyridazine API can be evaluated using a combination of identity, purity and physical-property tests appropriate to the agreed product specification.
Analytical controls may include:
A current commercial analytical specification reports HPLC purity of not less than 98.0 area% and melting point of 180–184°C.
Swapnroop Drugs and Pharmaceuticals provides pharmaceutical API manufacturing capabilities for Sulfamethoxypyridazine with quality-focused analytical evaluation and documentation.
Sulfamethoxypyridazine API can be manufactured and handled according to applicable customer specifications and relevant quality requirements. Analytical evaluation can cover identity, assay or purity, related substances and physical characteristics according to the agreed specification.
For pharmaceutical companies requiring Sulfamethoxypyridazine API from an India-based manufacturer, specification alignment, batch consistency, analytical control and appropriate documentation are important considerations.
Sulfamethoxypyridazine API should be stored in suitable, tightly closed pharmaceutical packaging to protect the material from moisture, contamination and excessive environmental exposure.
Recommended handling includes:
TCI identifies the material as moisture-sensitive and recommends cool, dark storage, with storage under inert gas for its analytical product.
Depending on customer and regulatory requirements, documentation may include:
Swapnroop Drugs and Pharmaceuticals focuses on pharmaceutical API manufacturing with quality systems, analytical evaluation and documentation intended to support pharmaceutical applications.
Sulfamethoxypyridazine API is handled according to defined quality requirements, with attention to identity, purity, impurities, physical properties and batch-to-batch consistency.
Customers can discuss Sulfamethoxypyridazine API requirements, applicable specifications, packaging and documentation with Swapnroop Drugs and Pharmaceuticals.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0 area% |
| Melting Point | 180–184°C |