Sucrose-Loaded Pellets are pharmaceutical-grade multiparticulate pellets in which sucrose is incorporated as the principal loaded component. Sucrose has CAS Number 57-50-1, molecular formula C₁₂H₂₂O₁₁, and molecular weight 342.30 g/mol.
Sucrose-based pharmaceutical pellets are used as spherical multiparticulate materials where controlled particle size, smooth surface characteristics and uniformity are important. Sucrose-containing spherical pellets are commonly manufactured from sucrose together with starch, and pharmaceutical sugar-sphere specifications define the sucrose content on a dried basis.
The Sucrose-Loaded Pellets format can be used for formulation development, coating, layering and multiparticulate oral dosage-form manufacturing. Depending on the intended application, the pellets may subsequently undergo functional coating or additional processing.
Unlike a simple Sucrose Pellets / Sugar Spheres product, the term Sucrose-Loaded Pellets can describe a formulation in which sucrose is intentionally incorporated or loaded into the pellet structure. Therefore, the exact sucrose loading, pellet size and finished-product specifications should be defined according to the individual SDP product specification.
Sucrose-loaded spherical pellets can serve as a formulation component where a controlled, uniform multiparticulate substrate is required.
The spherical surface can provide a suitable substrate for subsequent coating or layering operations.
The pellets can be incorporated into multiparticulate dosage-form development where defined particle-size distribution and pellet uniformity are required.
Depending on the formulation design and mechanical characteristics, sucrose-based pellets can be incorporated into capsule or multiparticulate tablet systems.
Sucrose-loaded pellets can be supplied in bulk with product-specific sucrose content, particle size and quality parameters.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 62.5–91.5% |
| Loss on Drying | NMT 4.0% |
| Residue on Ignition | NMT 0.25% |
| Heavy Metals | NMT 5 ppm |
| Water Content | NMT 4.0% |
| Specific Rotation | +41° to +61° |