Sodium Acetylated Hyaluronate is an acetylated derivative of Sodium Hyaluronate and is a specialty cosmetic ingredient used primarily in moisturising, humectant and skin-conditioning formulations. Its INCI name is SODIUM ACETYLATED HYALURONATE. It is produced by introducing acetyl groups onto the hydroxyl groups of Sodium Hyaluronate, giving the resulting polymer a modified balance of hydrophilic and lipophilic characteristics.
Unlike conventional Sodium Hyaluronate, Sodium Acetylated Hyaluronate is a chemically modified hyaluronate derivative. Acetylation can alter properties such as molecular interaction, surface affinity and hydration behavior. Commercial grades can also differ substantially in molecular weight and degree of acetylation, so these parameters are important when defining the raw-material specification.
It is generally supplied as a white powder or granules and is suitable for appropriately designed aqueous cosmetic formulations. Commercial technical information describes it as a water-soluble specialty ingredient for lotions, masks, essences and other skin-care products.
Sodium Acetylated Hyaluronate is the acetylated ester derivative of Sodium Hyaluronate. Unlike a conventional small molecule, it is a polymer with a variable degree of acetylation. Consequently, it does not have one universally applicable fixed molecular formula or molecular weight.
One commercial specification represents its structure as (C₁₄+2xH₂₀+2xNO₁₁+xNa)n, where x represents the degree of acetylation. Other commercial databases identify CAS 158254-23-0, while some suppliers use 287390-12-9 or 9067-32-7 for particular material representations. Because identifier assignment can vary between commercial grades and databases, the CAS number should be confirmed against the exact raw material supplied.
A published cosmetic study used fully acetylated Sodium Hyaluronate with an average molecular weight of approximately 15 kDa, demonstrating that molecular weight can be deliberately controlled during production.
Sodium Acetylated Hyaluronate is primarily used as a humectant and skin-conditioning cosmetic ingredient. Cosmetic ingredient databases identify humectant functionality, while commercial technical information describes its use for moisturising and skin-conditioning applications.
The acetylation of the hyaluronate backbone changes the physicochemical characteristics of the polymer. Commercial technical descriptions associate this modification with water retention, skin affinity and a non-greasy sensory profile. These characteristics make the ingredient relevant to modern hydration-focused formulations.
Published research has investigated Sodium Acetylated Hyaluronate in comparison with Sodium Hyaluronate of comparable molecular weight. In one study, the acetylated material had an average molecular weight of 15 kDa and was evaluated in skin models and a cosmetic formulation. The study should be viewed as evidence for the particular material and experimental conditions rather than as a universal performance claim for every Sodium Acetylated Hyaluronate grade.
Sodium Acetylated Hyaluronate can be used in a variety of skin-care and personal-care formulations, including moisturising creams, facial serums, essences, lotions, masks and other hydration-focused products. Commercial technical specifications specifically describe applications in moisturising and skin-care formulations.
Its water solubility makes it suitable for aqueous formulation systems. The selected molecular-weight and acetylation grade can influence dispersion, hydration, viscosity and sensory behavior, so the technical grade should be matched to the intended finished product.
A commercial specification reports a recommended use range of 0.01–0.1%, but this is a supplier-specific recommendation rather than a universal regulatory concentration. Formulators should establish the appropriate concentration through formulation testing and according to the applicable market requirements.
The two most important technical characteristics of Sodium Acetylated Hyaluronate are molecular weight and degree of acetylation. Commercial specifications can differ significantly in these parameters. One commercial grade specifies molecular weight of ≤100 kDa, while another grade specifies 10 kDa, illustrating the importance of identifying the exact grade.
A published cosmetic raw-material specification reports degree of acetylation of 2.85–3.90, pH 5.0–8.0, heavy metals NMT 20 ppm, arsenic NMT 2 ppm, and a total bacterial count of NMT 100 CFU/g. These values belong to that particular commercial specification and should not be treated as universal limits.
The Assay (HPLC) field should not be populated with an arbitrary percentage. Sodium Acetylated Hyaluronate is a polymeric derivative, and quality assessment can involve molecular weight, degree of acetylation, moisture, pH, ash, microbiological parameters and other product-specific tests. Therefore, the actual analytical method must be confirmed for the selected grade.
Sodium Acetylated Hyaluronate is a specialty cosmetic ingredient for manufacturers developing advanced moisturising, hydrating and skin-conditioning products. Its acetylated hyaluronate structure provides a differentiated option from conventional Hyaluronic Acid and Sodium Hyaluronate.
For B2B cosmetic raw-material sourcing, the technical specification should clearly identify the applicable CAS identifier, molecular-weight range, degree of acetylation, appearance, pH, moisture, heavy metals and microbiological requirements.
As a Sodium Acetylated Hyaluronate Cosmetic Ingredient Manufacturer in India, the focus is on controlled polymer characteristics, consistent raw-material quality and suitability for bulk cosmetic and personal-care formulation requirements.
| Parameter | Specification |
|---|---|
| Appearance | White or colourless crystals / white powder |
| Assay (HPLC) | 95.0% – 105.0% |
| Heavy Metals | NMT 20 ppm |
| pH (1% Solution) | 5.0–8.0 |