Salmon Calcitonin is a synthetic polypeptide hormone consisting of 32 amino acids and is structurally related to naturally occurring calcitonin. It acts primarily on bone and calcium metabolism by inhibiting osteoclastic bone resorption and reducing the release of calcium from bone.
Salmon Calcitonin is a peptide active pharmaceutical ingredient used in the development and manufacture of pharmaceutical formulations for conditions associated with abnormal bone turnover and calcium metabolism.
| Parameter | Details |
|---|---|
| Product Name | Salmon Calcitonin |
| Generic Name | Calcitonin |
| Peptide Type | 32-amino-acid peptide hormone |
| Source | Synthetic / recombinant peptide |
| Target | Calcitonin receptor |
| Therapeutic Class | Calcium-regulating hormone |
| Molecular Formula | C₁₄₅H₂₄₀N₄₂O₄₈S₂ |
| Molecular Weight | 3431.85 g/mol |
| CAS Number | 47931-85-1 |
| Physical Form | White to off-white lyophilized powder |
| Peptide Length | 32 amino acids |
Salmon Calcitonin is used in pharmaceutical formulations for conditions involving bone resorption and calcium metabolism, including certain indications involving osteoporosis and hypercalcemia. It has also been used in the management of Paget's disease of bone.
Salmon Calcitonin is manufactured using controlled peptide synthesis and purification processes. Quality evaluation of peptide APIs typically includes identity, purity, peptide content, related substances, water content, residual solvents, elemental impurities and biological activity where applicable.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | Conforms by HPLC and peptide identity / mass spectrometry |
| Assay (HPLC) | ≥95.0% peptide content |
| Loss on Drying | NMT 5.0% |
| Residue on Ignition | NMT 2.0% |
| pH (1% Solution) | 4.0 – 7.0 |
| Solubility | Soluble in water; soluble in dilute acidic aqueous solutions |