Poloxamer is a family of synthetic, nonionic triblock copolymers composed of polyoxyethylene (PEO) and polyoxypropylene (PPO) blocks. These polymers are widely used as functional pharmaceutical excipients because of their surfactant, solubilizing, emulsifying, wetting and stabilizing properties.
Poloxamers are commercially available in different grades, with Poloxamer 188 and Poloxamer 407 among the most commonly used pharmaceutical grades. The numerical designation identifies a particular polymer composition and does not represent one universal chemical substance.
Swapnroop Pharma manufactures and supplies Poloxamer in India for qualified pharmaceutical, nutraceutical, cosmetic and specialty formulation applications. The appropriate grade should be selected according to the required molecular-weight range, hydrophilic-lipophilic balance, viscosity and formulation performance.
Poloxamers are versatile nonionic surfactants used to improve the physical and formulation characteristics of pharmaceutical products.
Depending on the grade, Poloxamer can function as:
Poloxamers can improve the dispersion and apparent solubility of poorly water-soluble ingredients and help stabilize pharmaceutical formulations.
Applications may include:
Certain grades, particularly Poloxamer 407, exhibit thermoreversible gel-forming behavior and are therefore useful in selected topical and controlled-release formulation systems.
Poloxamer 188 is a highly hydrophilic nonionic surfactant commonly used for solubilization, stabilization, wetting and formulation development.
Poloxamer 407 has a higher proportion of polyoxypropylene relative to Poloxamer 188 and is widely recognized for its thermoreversible gelation behavior at suitable concentrations.
The exact properties of each Poloxamer grade depend on its polymer composition and molecular-weight characteristics.
Poloxamers have an ABA-type triblock structure, generally represented as:
PEO–PPO–PEO
where PEO represents polyoxyethylene and PPO represents polyoxypropylene.
Because Poloxamer is a family of polymers, its molecular formula and molecular weight are grade-dependent. The material may be supplied as a white or almost white powder, granules, flakes or waxy solid depending on the specific grade.
Swapnroop Pharma supplies pharmaceutical-grade Poloxamer to pharmaceutical manufacturers, formulation developers, nutraceutical companies and other qualified customers.
Grade selection can be aligned with requirements for:
Poloxamer should be stored in tightly closed, moisture-protective packaging in a cool, dry and clean environment. Excessive heat, humidity and contamination should be avoided.
Storage conditions should follow the approved product specification and SDS for the selected grade.
Depending on the selected grade and customer requirements, documentation may include:
Swapnroop Pharma supplies Poloxamer for qualified pharmaceutical, nutraceutical, cosmetic and specialty formulation applications in India and international markets.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |