Plerixafor is a pharmaceutical active ingredient and a CXCR4 chemokine receptor antagonist used as a hematopoietic stem cell mobilizer. It is identified by CAS Number 110078-46-1, with the molecular formula C₂₈H₅₄N₈ and molecular weight 502.80 g/mol. Plerixafor is used in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells for collection and subsequent autologous transplantation. (pubchem.ncbi.nlm.nih.gov)
Plerixafor API is a synthetic azamacrocyclic compound consisting of two cyclam rings connected through a 1,4-phenylenebis(methylene) linker. It acts by inhibiting the CXCR4 chemokine receptor and blocking the interaction between CXCR4 and its ligand stromal cell-derived factor-1α (SDF-1α). (dailymed.nlm.nih.gov)
Plerixafor is also known by the development code AMD3100 and is the active ingredient used in plerixafor injection products.
Plerixafor has the molecular formula C₂₈H₅₄N₈ and molecular weight 502.80 g/mol. PubChem reports an exact mass of 502.44714376 Da, hydrogen-bond donor count of 6, hydrogen-bond acceptor count of 8, rotatable bond count of 4, and topological polar surface area of 78.7 Ų. (pubchem.ncbi.nlm.nih.gov)
Key chemical identifiers include:
DailyMed identifies Plerixafor as a white to off-white crystalline solid and reports a typical melting point of 131.5°C. (dailymed.nlm.nih.gov)
Plerixafor is a hematopoietic stem cell mobilizer used in combination with filgrastim to mobilize hematopoietic stem cells into peripheral blood for collection and subsequent autologous transplantation.
Its pharmaceutical applications include:
The current U.S. labeling identifies plerixafor injection for use in combination with filgrastim to mobilize hematopoietic stem cells in patients with non-Hodgkin's lymphoma or multiple myeloma. (dailymed.nlm.nih.gov)
Plerixafor has an established USP-NF monograph. USP defines Plerixafor as containing NLT 97.0% and NMT 103.0% of C₂₈H₅₄N₈, calculated on the anhydrous basis. USP also identifies USP Plerixafor Reference Standard and USP Plerixafor System Suitability Mixture as reference materials. (doi.usp.org)
Analytical characterization may include HPLC assay and related-substance testing, spectroscopic identification and other applicable compendial procedures.
Plerixafor is hygroscopic, so water-content control and suitable moisture-protective packaging are important considerations during API handling and storage.
Plerixafor API is identified by CAS 110078-46-1, molecular formula C₂₈H₅₄N₈, and molecular weight 502.80 g/mol. Its established USP-NF monograph provides a recognized compendial framework for API quality assessment. (doi.usp.org)
Quality evaluation can include identification, assay, related substances, water content and other applicable pharmaceutical quality-control tests according to the approved specification and current pharmacopoeial requirements.
Plerixafor is hygroscopic and should therefore be packaged in tightly closed, moisture-protective pharmaceutical-grade containers.
The USP reference-standard SDS describes Plerixafor as a white/off-white powder and reports it as soluble in water. Commercial API storage should follow the applicable stability data, packaging configuration and approved product specification. (cymitquimica.com)
Applicable documentation may include:
Plerixafor is a well-characterized hematopoietic stem cell mobilizer with an established USP-NF monograph. Its CAS Number 110078-46-1, molecular formula C₂₈H₅₄N₈, and molecular weight 502.80 g/mol provide clear chemical identification. (pubchem.ncbi.nlm.nih.gov)
The USP monograph specifies an assay range of 97.0–103.0% on the anhydrous basis, providing a reliable compendial reference for quality evaluation. Plerixafor's hygroscopic nature also makes appropriate packaging, moisture control and storage important aspects of API quality management. (doi.usp.org
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 97.0–103.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.2% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 0.5% |
| Water Content | NMT 0.5% |
| Melting Point | 131.5°C |