Piromidic Acid is a synthetic antibacterial active pharmaceutical ingredient belonging to the pyridopyrimidine and quinolone-related class of antibacterial compounds. It is identified by CAS Number 19562-30-2, with the molecular formula C₁₄H₁₆N₄O₃ and molecular weight 288.30 g/mol. Piromidic Acid has primarily been associated with antibacterial activity against Gram-negative organisms and has been used for urinary tract and intestinal infections.
Piromidic Acid API is a small-molecule antibacterial compound chemically known as 8-ethyl-5-oxo-2-pyrrolidin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid. It is listed in pharmaceutical and chemical databases under CAS 19562-30-2 and FDA GSRS UNII 3I12WH4EWF.
Piromidic Acid is available as the parent acid and should be distinguished from related antibacterial compounds such as Pipemidic Acid, which has a different molecular structure and CAS Number.
Piromidic Acid has the molecular formula C₁₄H₁₆N₄O₃ and molecular weight 288.30 g/mol. Its PubChem chemical profile reports an exact mass of 288.12224039 Da, XLogP3 of 1.3, hydrogen-bond donor count of 1, hydrogen-bond acceptor count of 7, rotatable bond count of 3, and topological polar surface area of 86.6 Ų.
The compound is a monocarboxylic acid containing a pyridopyrimidine nucleus and pyrrolidine substituent. Piromidic Acid is classified as a synthetic organic compound and antibacterial drug.
Piromidic Acid has been recognized as an antibacterial agent with activity primarily against Gram-negative bacteria. Medical and pharmacological references associate its use with urinary tract and intestinal infections.
Potential pharmaceutical and analytical applications of Piromidic Acid API include:
Piromidic Acid can be characterized using chromatographic and spectroscopic analytical techniques, including HPLC, titration, mass spectrometry and other appropriate identity and purity methods.
FUJIFILM Wako lists Piromidic Acid Standard for HPLC with specifications of NLT 99.0% by HPLC and NLT 99.0% by titration. Its listed appearance is nearly white to pale-yellow powder and its melting point is 314–316°C. These values apply to the cited analytical reference standard and should not automatically be represented as a universal pharmacopoeial API specification.
A separate commercial reference source reports Piromidic Acid purity of >99%, while another research-grade source reports ≥95% purity. Therefore, the applicable commercial/API specification should be determined from the approved product specification and batch CoA.
Piromidic Acid API is identified by CAS 19562-30-2, molecular formula C₁₄H₁₆N₄O₃, and molecular weight 288.30 g/mol. Its well-defined chemical identity supports pharmaceutical research, analytical testing and API development applications.
Quality evaluation can include identity confirmation, chromatographic purity, assay, related-substance evaluation and other tests defined in the applicable product specification. Technical documentation can be provided according to the relevant grade and batch requirements.
Piromidic Acid should be packaged in suitable, tightly closed containers that protect the material from moisture, contamination and unsuitable environmental exposure.
Research-grade references report storage at −20°C, while FUJIFILM Wako's HPLC analytical standard specifies storage at 2–10°C. Because storage conditions differ according to grade, packaging and intended application, the applicable product specification and stability information should be followed for commercial API material.
Applicable documentation may include:
Piromidic Acid is a well-characterized antibacterial compound with a defined molecular structure and established chemical identifiers. Its CAS Number 19562-30-2, molecular formula C₁₄H₁₆N₄O₃, and molecular weight 288.30 g/mol provide clear identification for pharmaceutical and analytical applications.
The availability of validated analytical-reference data, including 99.0% minimum HPLC and titration values for the FUJIFILM Wako reference standard, provides useful support for analytical characterization. Commercial API quality requirements should always be evaluated against the applicable approved specification and batch-specific Certificate of Analysis.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.2% |
| Residue on Ignition | NMT 0.1% |
| Individual Impurity | NMT 0.10% |
| Total Impurities | NMT 0.5% |