Pipazethate, also known as Pipazetate, is a pharmaceutical compound belonging to the pyridobenzothiazine class and is recognized as a non-narcotic oral antitussive agent. It has been associated with the treatment of cough and pharmaceutical formulations intended for cough suppression.
Pipazethate has the molecular formula C₂₁H₂₅N₃O₃S, a molecular weight of 399.507 g/mol, and CAS Number 2167-85-3. NIST identifies Pipazethate under CAS 2167-85-3 and lists several synonyms, including Pipazetate, D-254, SKF 70230-A and SQ 15,874.
Pipazethate is a synthetic pharmaceutical active ingredient associated primarily with antitussive applications. PubChem identifies it as a non-narcotic oral antitussive agent and lists its indication as treatment of cough.
The chemical name of Pipazethate is 2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate. It is listed as a solid substance in PubChem.
Pipazethate API is associated with pharmaceutical preparations used for cough suppression. Potential pharmaceutical applications include:
PubChem identifies Pipazethate as a non-narcotic oral antitussive and records its drug indication as treatment of cough.
Pipazethate intended for pharmaceutical manufacturing should be evaluated using validated analytical procedures appropriate to the intended specification. Depending on the application and applicable quality standard, analytical evaluation may include identity, assay, related substances, residual solvents, water content and other relevant quality attributes.
No current universal USP/IP/Ph. Eur. numerical monograph specification for Pipazethate free base was verified in the sources reviewed. Therefore, numerical assay, impurity, loss-on-drying and residue-on-ignition limits should not be presented as universal pharmacopoeial requirements without an applicable approved specification.
Pipazethate API intended for pharmaceutical use should be manufactured under appropriate quality systems and tested against the applicable product specification. Documentation and analytical testing can be provided according to the requirements applicable to the intended pharmaceutical market and formulation.
Pipazethate can be considered for pharmaceutical development and manufacturing applications where the compound is used as an antitussive active ingredient.
Pipazethate, also known as Pipazetate, is a pharmaceutical compound associated with antitussive applications. It is identified by CAS Number 2167-85-3, molecular formula C₂₁H₂₅N₃O₃S, and molecular weight 399.507 g/mol.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Melting Point | 50–53°C |