Pipazetate, also known as Pipazethate, is a synthetic pharmaceutical compound belonging to the pyridobenzothiazine class. It is identified as an antitussive agent and has been used in pharmaceutical preparations for the symptomatic treatment of cough. The FDA Global Substance Registration System lists the substance as PIPAZETHATE, with CAS Number 2167-85-3 and UNII M5EK1T5V2L.
Pipazetate has the molecular formula C₂₁H₂₅N₃O₃S and a molecular weight of approximately 399.51 g/mol. NIST lists CAS 2167-85-3 and the molecular weight as 399.507 g/mol.
Pipazetate is also referred to as Pipazethate, D-254, SKF 70230-A and SQ 15,874. Its systematic chemical description is 2-(2-piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate.
The compound has been described as an antitussive pharmaceutical ingredient. Historical pharmaceutical literature also describes analytical methods for the determination of Pipazethate Hydrochloride in bulk material and pharmaceutical preparations.
Pipazetate has been associated primarily with pharmaceutical preparations used as antitussive agents. It may be relevant to:
Pipazethate is classified under ATC code R05DB11 in the FDA GSRS record.
Pipazetate should be evaluated using validated analytical procedures appropriate to the intended pharmaceutical application. Published analytical literature describes spectrophotometric and HPLC procedures for quantitative determination of Pipazethate Hydrochloride in pure material and pharmaceutical formulations.
Because I did not find a current authoritative USP/IP/Ph. Eur. monograph establishing universal numerical release specifications for the Pipazetate free base, numerical assay, impurity and loss-on-drying limits should not be presented as pharmacopoeial requirements unless they are supported by the specific approved specification for the material.
Pipazetate API intended for pharmaceutical use should be manufactured and tested under appropriate quality systems. Product testing can include identity, assay, related substances, residual solvents, water content and other applicable quality attributes according to the agreed or regulatory specification.
The API can be considered for pharmaceutical development, analytical work and applicable antitussive formulation requirements.
Pipazetate, also known as Pipazethate, is a pharmaceutical compound associated with antitussive applications. The parent compound is identified by CAS 2167-85-3, molecular formula C₂₁H₂₅N₃O₃S, and molecular weight 399.51 g/mol.
| Parameter | Specification |
|---|---|
| Appearance | white to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Individual Impurity | NMT 0.5% |
| Water Content | NMT 0.5% |
| Melting Point | 50–53°C (reported) |