Palmitoyl Tetrapeptide-7 is a palmitoylated cosmetic peptide consisting of a lipophilic palmitoyl group attached to the tetrapeptide sequence Gly-Gln-Pro-Arg (GQPR). It is also known by names including Pal-GQPR, N-Palmitoylrigin and, in some references, Palmitoyl Tetrapeptide-3.
The palmitoyl group gives the peptide a more lipophilic character, which is relevant to its use in topical cosmetic formulations. Palmitoyl Tetrapeptide-7 is primarily positioned as a skin-conditioning cosmetic ingredient and is commonly used in premium skin-care formulations such as serums, creams, moisturizers and eye-care products.
It is frequently combined with other cosmetic peptides, particularly Palmitoyl Tripeptide-1, in peptide-based anti-aging formulations. Commercial ingredient systems such as Matrixyl 3000 contain both Palmitoyl Tetrapeptide-7 and Palmitoyl Tripeptide-1.
Palmitoyl Tetrapeptide-7 is a synthetic lipopeptide cosmetic ingredient based on the tetrapeptide sequence GQPR.
Its key characteristics include:
CAS No.: 221227-05-0
INCI Name: Palmitoyl Tetrapeptide-7
Common Name: Pal-GQPR
Peptide Sequence: Gly-Gln-Pro-Arg
Molecular Formula: C34H62N8O7
Molecular Weight: approximately 694.9 g/mol.
Important CMS note: Some commercial and database pages incorrectly or inconsistently associate other CAS numbers with this ingredient. For the defined molecule Palmitoyl Tetrapeptide-7 / Pal-GQPR, use 221227-05-0 as the primary CAS reference and verify it against the actual supplier COA/SDS before publishing.
GQPR
The full chemical identity is described as N-palmitoyl-glycyl-L-glutaminyl-L-prolyl-L-arginine.
Palmitoyl Tetrapeptide-7 is primarily used as a skin-conditioning ingredient in cosmetic formulations.
It is particularly suitable for formulations positioned around:
Cosmetic ingredient references list its principal function under skin conditioning, while commercial cosmetic literature commonly positions it in anti-aging formulations.
Palmitoyl Tetrapeptide-7 can be incorporated into suitable facial serum formulations.
Potential applications include:
The appropriate concentration should be determined from the specific commercial grade and finished-formula requirements.
Suitable applications include:
It can be incorporated into suitable emulsion systems while considering the supplier's recommended processing conditions.
Palmitoyl Tetrapeptide-7 is also found in formulations intended for the eye area, including:
Commercial ingredient references specifically identify eye creams among its cosmetic applications.
Important factors include:
Avoid unnecessary exposure to high temperatures. The supplier's recommended processing temperature should be followed.
Finished-product pH should be selected according to the stability data for the specific commercial grade.
Because Palmitoyl Tetrapeptide-7 contains a long palmitoyl chain, its practical aqueous solubility can be limited and is dependent on the commercial form and formulation system.
For neat peptide material, storage requirements are grade-specific. One current analytical supplier lists the material as heat-, air- and moisture-sensitive and recommends frozen storage under inert gas.
Therefore, the actual SDP commercial grade should follow its own supplier-recommended storage conditions.
Palmitoyl Tetrapeptide-7 is frequently formulated alongside other cosmetic peptides.
A notable combination is:
Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7
This combination is commercially used in peptide-based skin-care ingredient systems.
Palmitoyl Tetrapeptide-7 can be considered for:
Palmitoyl Tetrapeptide-7 is a palmitoylated tetrapeptide cosmetic ingredient based on the Gly-Gln-Pro-Arg (GQPR) sequence.
The CAS number for the defined molecule is 221227-05-0.
The INCI name is Palmitoyl Tetrapeptide-7.
It is commonly referred to as Pal-GQPR and N-Palmitoylrigin.
The peptide sequence is Gly-Gln-Pro-Arg (GQPR).
It is primarily used as a skin-conditioning cosmetic ingredient and is commonly incorporated into peptide-based skin-care products.
Yes. It is used in suitable serum and other leave-on skin-care formulations.
Yes. It can be incorporated into suitable creams, moisturizers and eye-care formulations.
The molecular formula is C34H62N8O7.
The molecular weight is approximately 694.9 g/mol.
The names Palmitoyl Tetrapeptide-3 and Palmitoyl Tetrapeptide-7 have been used for the same molecular entity in some databases and references. For the SDP page, use the current INCI name Palmitoyl Tetrapeptide-7.
| Parameter | Specification |
|---|---|
| Appearance | White to off-white powder |