Nomegestrol is a synthetic steroidal progestogen and a derivative of 19-norprogesterone. It is the parent compound of nomegestrol acetate and has a defined steroidal structure with progestogenic activity.
Nomegestrol has the CAS Number 58691-88-6, molecular formula C21H28O3, and molecular weight 328.40 g/mol. Its chemical identity is documented in PubChem and FDA Global Substance Registration System records.
Nomegestrol is a specialized steroidal pharmaceutical compound relevant to progestogen research, hormonal pharmaceutical development and analytical applications.
Important quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities, optical rotation and solid-state characteristics, according to the applicable API specification.
CAS Number: 58691-88-6
Molecular Formula: C21H28O3
Molecular Weight: 328.40 g/mol
Chemical Name: 17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
Synonyms: 19-Normegestrol; Nomegestrolum
Drug Class: Progestogen
Therapeutic Class: Hormonal / Progestogenic Compound
Molecule Type: Synthetic Small Molecule
PubChem CID: 68783
FDA UNII: 10F89177CO
ChEMBL ID: CHEMBL2105722
These identifiers are reported by PubChem and associated authoritative databases.
Nomegestrol is a progestogenic steroid that acts primarily through interaction with progesterone receptors. Activation of progesterone-receptor pathways influences transcription of progesterone-responsive genes and produces characteristic progestogenic effects.
Nomegestrol should not be confused with nomegestrol acetate, which is its acetate ester and a separate pharmaceutical substance. Nomegestrol acetate has CAS 58652-20-3, formula C23H30O4, and molecular weight 370.48 g/mol.
Nomegestrol is relevant to:
Nomegestrol is a steroidal crystalline small molecule. PubChem reports a molecular weight of 328.40 g/mol, XLogP3-AA of 2.0, and topological polar surface area of 54.4 Ų.
Nomegestrol is also identified as impurity B in the European Pharmacopoeia monograph for nomegestrol acetate, providing an important analytical connection between the parent compound and the acetate pharmaceutical substance.
Nomegestrol is relevant to research involving:
Typical Nomegestrol API quality-control testing may include:
Final numerical acceptance criteria should be based on the applicable validated API specification.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.2% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 0.5% |
| Melting Point | Approximately 220–224°C |