Nicergoline is a semi-synthetic ergoline derivative used as a pharmaceutical active ingredient. It is structurally related to ergot alkaloids and is characterized by activity involving alpha-adrenergic and serotonergic receptors.
Nicergoline is used in pharmaceutical development, particularly in products associated with cerebrovascular and peripheral vascular applications.
Nicergoline is a specialized pharmaceutical API with defined chemical, stereochemical and physicochemical characteristics. Quality evaluation includes identification, assay, related substances, water content, sulfated ash and optical rotation.
CAS Number: 27848-84-6
Molecular Formula: C24H26BrN3O3
Molecular Weight: 484.40 g/mol
IUPAC Name: [(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinolin-9-yl]methyl 5-bromopyridine-3-carboxylate
Drug Class: Ergot Derivative
Therapeutic Area: Neurology / Vascular Medicine
Molecule Type: Semi-synthetic Small Molecule
PubChem confirms CAS 27848-84-6, formula C24H26BrN3O3 and molecular weight 484.4 g/mol.
Nicergoline is an ergot-derived compound with pharmacological activity at several receptor systems.
Its pharmacological properties include:
Nicergoline API is used in pharmaceutical development for:
According to the BP 2025 monograph, Nicergoline occurs as a fine to granular, white or yellowish powder. It is practically insoluble in water, freely soluble in methylene chloride and soluble in ethanol (96%). Nicergoline also exhibits polymorphism.
A controlled Nicergoline API manufacturing process may involve:
Nicergoline quality testing can include:
The BP monograph specifies 99.0%–101.0% content on an anhydrous basis, water NMT 0.5%, and sulfated ash NMT 0.1%.
Nicergoline is relevant to research involving:
Store Nicergoline API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light. Actual storage conditions should follow the manufacturer's validated stability data and approved specification.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.2% |
| Water Content | NMT 0.5% |
| Specific Rotation | +4.8° to +5.8° |