Nandrolone is a synthetic anabolic-androgenic steroid (AAS) and a derivative of testosterone. It is a 19-nor steroid characterized by the absence of the methyl group at the C-19 position of the steroid nucleus.
Nandrolone has anabolic and androgenic activity and is used as an active pharmaceutical ingredient in the development and manufacture of certain steroid-based pharmaceutical formulations. Nandrolone is also an important reference compound in pharmaceutical, analytical and steroid research.
Nandrolone is a well-characterized steroidal pharmaceutical API with applications in pharmaceutical formulation development, analytical testing and research involving anabolic-androgenic steroid compounds.
Important API quality attributes include identity, assay, related substances, water content, residual solvents, elemental impurities and other applicable pharmaceutical quality parameters.
CAS Number: 434-22-0
Molecular Formula: C18H26O2
Molecular Weight: 274.40 g/mol
Chemical Name: 17β-Hydroxyestra-4-en-3-one
IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Drug Class: Anabolic-Androgenic Steroid
Therapeutic Class: Anabolic Steroid
Therapeutic Area: Endocrinology / Musculoskeletal
Molecule Type: Synthetic Small Molecule
Nandrolone exerts its pharmacological effects primarily through interaction with the androgen receptor, a nuclear steroid hormone receptor.
Its activity includes:
Nandrolone is a 19-nor testosterone derivative and has a different androgenic/anabolic activity profile from testosterone.
Nandrolone API is relevant to:
Nandrolone has historically been used in certain pharmaceutical formulations for conditions involving anemia and muscle or tissue wasting, depending on the specific nandrolone ester, formulation and regulatory jurisdiction.
Nandrolone itself should be distinguished from its pharmaceutical esters.
Important nandrolone derivatives include:
These esterified forms have different chemical identities, CAS numbers, molecular weights and pharmacokinetic properties.
Therefore, a Nandrolone API page should not use the specifications of Nandrolone Decanoate or Nandrolone Phenylpropionate.
Nandrolone is generally described as a white or almost white crystalline powder. It is practically insoluble in water and has greater solubility in various organic solvents.
Its physical characteristics, particle properties and crystalline form should be controlled according to the applicable pharmaceutical specification.
A controlled Nandrolone API manufacturing process may involve:
Typical Nandrolone API testing may include:
Store Nandrolone API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Final storage conditions should be established according to validated stability data and the applicable API specification.
Nandrolone is relevant to research involving:
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |