Nafamostat is a synthetic serine protease inhibitor with broad inhibitory activity against enzymes involved in coagulation, fibrinolysis, complement activation and other proteolytic pathways. It inhibits proteases including thrombin, plasmin, kallikrein, trypsin, and coagulation factors such as VIIa, Xa and XIIa.
Nafamostat has a rapid onset and short duration of action and has been used particularly in Asian countries as an anticoagulant during extracorporeal circulation and renal replacement therapies. It has also been used in pharmaceutical applications involving pancreatitis and disseminated intravascular coagulation, depending on the country and approved indication.
The free-base compound is identified by CAS 81525-10-2, molecular formula C₁₉H₁₇N₅O₂, and molecular weight 347.4 g/mol.
Nafamostat is also known by the development code FUT-175. Its pharmaceutical activity is primarily associated with rapid inhibition of serine proteases.
For pharmaceutical formulation, Nafamostat is commonly encountered as Nafamostat Mesylate/Mesilate, a salt form containing two methanesulfonic acid components. PubChem lists Nafamostat Mesylate with CAS 82956-11-4 and molecular weight 539.6 g/mol.
Nafamostat's most established pharmaceutical applications relate to its anticoagulant and protease-inhibitory properties.
Nafamostat is used in Asian countries as an anticoagulant during continuous renal replacement therapy and extracorporeal circulation.
SEO/content recommendation: Do not state that all of these are universally approved indications. Regulatory status and approved uses vary by country.
Nafamostat works by rapidly inhibiting serine proteases.
It can inhibit several enzymes involved in the coagulation and fibrinolytic systems, including:
It also inhibits components of the complement system and pancreatic proteases. This broad protease inhibition contributes to its anticoagulant and antiproteolytic effects.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |