Moxisylyte, also known as Thymoxamine, is a synthetic pharmaceutical compound belonging to the alpha-1 adrenergic receptor antagonist class. It has been investigated and used in pharmaceutical applications involving vascular smooth-muscle relaxation and urological disorders.
Moxisylyte acts by blocking alpha-1 adrenergic receptors, which can reduce adrenergic-mediated vasoconstriction and promote relaxation of vascular smooth muscle. It has historically been used in the management of conditions including erectile dysfunction and Raynaud's disease, depending on its pharmaceutical form and market.
Moxisylyte free base has the molecular formula C₁₆H₂₅NO₃, molecular weight 279.3746 g/mol, and is an achiral compound with no optical activity.
Moxisylyte is a substituted phenoxyethyl dimethylamine derivative with alpha-adrenergic blocking activity. It has been marketed or investigated in different pharmaceutical applications, including urological use.
The hydrochloride salt, Moxisylyte Hydrochloride, is a separately identified pharmaceutical substance with CAS 964-52-3 and molecular weight approximately 315.83 g/mol.
Moxisylyte has been used as an alpha-adrenergic blocking agent.
Historical pharmaceutical applications include:
NCATS identifies moxisylyte as an alpha-1 adrenergic antagonist and reports its historical use in erectile dysfunction.
For your commercial API page, avoid presenting every historical or investigational application as a currently approved indication worldwide.
Moxisylyte acts primarily as an alpha-1 adrenergic receptor antagonist.
Alpha-1 adrenergic receptors participate in vasoconstriction and contraction of vascular smooth muscle. By blocking these receptors, moxisylyte reduces alpha-adrenergic-mediated smooth-muscle contraction and promotes vasodilation.
This pharmacological activity forms the basis for its historical applications in vascular and urological conditions.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |