Moxifloxacin Hydrochloride is the hydrochloride salt of moxifloxacin, a synthetic fluoroquinolone antibacterial active pharmaceutical ingredient (API). It is used in pharmaceutical formulation development and manufacturing for antibacterial products. Moxifloxacin exerts its antibacterial activity primarily through inhibition of bacterial DNA gyrase and topoisomerase IV.
Moxifloxacin Hydrochloride has CAS Number 186826-86-8, molecular formula C21H24FN3O4·HCl, and molecular weight 437.89 g/mol.
Moxifloxacin Hydrochloride is an established pharmaceutical API used in the development of oral and ophthalmic antibacterial formulations. The API is characterized through analytical parameters including identity, assay, related substances, water content, residual solvents and other applicable quality attributes.
CAS Number: 186826-86-8
Alternate CAS / CAS 2: 192927-63-2 (Moxifloxacin Hydrochloride Monohydrate)
Molecular Formula: C21H24FN3O4·HCl
Molecular Weight: 437.89 g/mol
Chemical Name: 1-Cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride
Drug Class: Fluoroquinolone Antibacterial
Therapeutic Class: Antibacterial
Therapeutic Area: Infectious Diseases / Ophthalmology
Molecule Type: Synthetic Small Molecule
Moxifloxacin Hydrochloride acts through inhibition of bacterial DNA gyrase and topoisomerase IV.
Its antibacterial activity involves:
Moxifloxacin Hydrochloride API is used in the development of:
Moxifloxacin is a broad-spectrum fluoroquinolone antibacterial compound with activity against a variety of susceptible Gram-positive and Gram-negative bacteria and selected atypical microorganisms.
Its hydrochloride salt form is used as the active pharmaceutical ingredient in various pharmaceutical development programs.
Moxifloxacin Hydrochloride is generally characterized as a crystalline solid. The precise particle size, polymorphic characteristics, water content and other physical attributes should be controlled according to the applicable API specification.
The monohydrate form contains water of crystallization and has a different molecular weight from anhydrous Moxifloxacin Hydrochloride.
A controlled Moxifloxacin Hydrochloride API manufacturing process may include:
Typical quality-control testing may include:
Moxifloxacin Hydrochloride API should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light. Final storage conditions should be based on validated stability data and the applicable approved API specification.
Moxifloxacin Hydrochloride is relevant to research involving:
Moxifloxacin Hydrochloride is a fluoroquinolone antibacterial API with CAS Number 186826-86-8, molecular formula C21H24FN3O4·HCl, and molecular weight 437.89 g/mol. It inhibits bacterial DNA gyrase and topoisomerase IV and is used in pharmaceutical development for antibacterial formulations.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 324°C, with decomposition |