Moxifloxacin Hydrochloride (Moxifloxacin HCl) is a synthetic fluoroquinolone antibacterial API used in the development and manufacture of pharmaceutical formulations. It is the hydrochloride salt of moxifloxacin and acts primarily by inhibiting bacterial DNA gyrase and topoisomerase IV.
Moxifloxacin Hydrochloride is identified by CAS Number 186826-86-8, with the molecular formula C21H24FN3O4·HCl and molecular weight of approximately 437.89 g/mol. USP defines Moxifloxacin Hydrochloride as containing 98.0% to 102.0% of moxifloxacin hydrochloride, calculated on the anhydrous basis.
Moxifloxacin HCl is an established antibacterial pharmaceutical API used for formulation development, pharmaceutical manufacturing and analytical research. Its quality evaluation includes chemical identification, assay, related substances, water content and other applicable quality attributes.
Moxifloxacin Hydrochloride is also available as a monohydrate form, which has a different molecular formula and molecular weight. The monohydrate is identified by CAS Number 192927-63-2 and molecular weight approximately 455.9 g/mol.
CAS Number: 186826-86-8
Alternate CAS / CAS 2: 192927-63-2 (Moxifloxacin Hydrochloride Monohydrate)
Molecular Formula: C21H24FN3O4·HCl
Molecular Weight: 437.89 g/mol
Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid monohydrochloride
Drug Class: Fluoroquinolone Antibacterial
Therapeutic Class: Antibacterial
Therapeutic Area: Infectious Diseases
Molecule Type: Synthetic Small Molecule
Moxifloxacin inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV.
Its antibacterial activity includes:
By interfering with essential bacterial DNA processes, Moxifloxacin inhibits bacterial growth and contributes to bacterial cell death.
Moxifloxacin HCl API is used in pharmaceutical development for:
Moxifloxacin is a broad-spectrum fluoroquinolone antibacterial compound with activity against susceptible Gram-positive and Gram-negative bacteria, as well as selected atypical and anaerobic organisms.
It is used as an active pharmaceutical ingredient in different pharmaceutical dosage-form development programs, depending on the applicable regulatory requirements and formulation.
Moxifloxacin Hydrochloride is a crystalline pharmaceutical substance. Its exact physical appearance, particle characteristics and solid-state properties should be controlled according to the applicable API specification.
Moxifloxacin Hydrochloride Monohydrate is a distinct solid form containing one molecule of water per moxifloxacin hydrochloride molecule and should not be confused with the anhydrous hydrochloride form.
A controlled Moxifloxacin HCl API manufacturing process may involve:
Typical Moxifloxacin HCl API testing may include:
Store Moxifloxacin HCl API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light. Final storage requirements should follow validated stability data and the approved product specification.
Moxifloxacin Hydrochloride is relevant to research involving:
Moxifloxacin Hydrochloride is a fluoroquinolone antibacterial API with CAS Number 186826-86-8, molecular formula C21H24FN3O4·HCl, and molecular weight approximately 437.89 g/mol. It inhibits bacterial DNA gyrase and topoisomerase IV and is widely used in antibacterial pharmaceutical development.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 324°C (decomposition) |