Moracizine, also known as Moricizine, is a synthetic antiarrhythmic active pharmaceutical ingredient belonging to the phenothiazine class. It has been used in pharmaceutical applications involving the management of serious ventricular cardiac arrhythmias.
Moracizine acts on cardiac electrical conduction, primarily through inhibition of sodium-dependent impulse conduction. It has historically been classified as a Class I antiarrhythmic agent.
The free-base form of Moracizine has the molecular formula C₂₂H₂₅N₃O₄S, molecular weight 427.52 g/mol, and CAS Number 31883-05-3.
Moracizine is a phenothiazine-derived pharmaceutical compound developed for antiarrhythmic applications. Its pharmacological activity is associated with modulation of cardiac ion-channel activity and reduction of abnormal electrical impulse conduction.
Moracizine has also been known by the development code EN-313 and the former brand name Ethmozine.
Moracizine has historically been used as an antiarrhythmic pharmaceutical ingredient for the treatment and prevention of serious ventricular arrhythmias.
Its pharmaceutical application is associated with modulation of cardiac electrical conduction and reduction of abnormal ventricular rhythm activity.
Regulatory note: Moracizine/moricizine has been discontinued or withdrawn in certain markets, so your website should avoid claiming that it is currently approved or commercially available in every country.
Moracizine is an antiarrhythmic compound that affects cardiac electrical activity. Its principal pharmacological action is associated with sodium-channel blockade, which can reduce the rate of cardiac depolarization and slow electrical impulse conduction.
This activity can influence abnormal cardiac rhythm and forms the basis of its historical antiarrhythmic application.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 1.0% |
| Melting Point | 156–157°C |