Moracizine, also known as Moricizine, is a synthetic antiarrhythmic active pharmaceutical ingredient belonging to the phenothiazine class. It has been used as an antiarrhythmic agent for the management of serious ventricular rhythm disturbances. FDA's substance database identifies Moracizine/Moracizine as an achiral chemical substance with the CAS Number 31883-05-3.
Moracizine has the molecular formula C₂₂H₂₅N₃O₄S and molecular weight 427.52 g/mol. It is also known by the development code EN-313 and has been associated with the trade name Ethmozine.
Moracizine is a phenothiazine derivative with antiarrhythmic activity. It affects cardiac electrical activity primarily through inhibition of sodium-dependent cardiac impulse conduction and has historically been classified among Class I antiarrhythmic agents.
Moracizine was previously used for the prophylaxis and treatment of serious and potentially life-threatening ventricular arrhythmias.
Moracizine has historically been used as an antiarrhythmic pharmaceutical ingredient for the prophylaxis and treatment of serious ventricular arrhythmias.
Its pharmacological application is associated with modulation of cardiac electrical conduction and reduction of abnormal ventricular rhythm activity.
Note for your website: Because moracizine has been withdrawn/discontinued from some markets, avoid writing that it is a currently approved treatment worldwide. Regulatory status and availability vary by country.
Moracizine is an antiarrhythmic compound that affects cardiac ion-channel activity and reduces abnormal electrical impulse conduction.
It is associated particularly with blockade of fast sodium channels involved in the rapid depolarization phase of the cardiac action potential. This can reduce excitability and slow conduction of electrical impulses through cardiac tissue.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |