Monoammonium Glycyrrhizinate is a licorice-derived ingredient produced from glycyrrhizin and supplied as its monoammonium salt. It is also known as Glycyrrhizic Acid Monoammonium Salt, Glycyrrhizin Monoammonium Salt, and Ammonium Glycyrrhizate. The ingredient is used in selected cosmetic, personal-care, and flavour-related formulations, depending on the grade and applicable regulatory requirements.
The compound is associated with glycyrrhizin, a naturally occurring triterpenoid saponin found in licorice root, commonly sourced from Glycyrrhiza glabra. Unlike a crude licorice extract, Monoammonium Glycyrrhizinate is a defined salt ingredient with its own identity, purity, and analytical specifications.
Monoammonium Glycyrrhizinate is commonly identified by CAS Number 53956-04-0. Its molecular formula is C₄₂H₆₅NO₁₆, and its molecular weight is approximately 839.97 g/mol. Reference sources may report a slightly different formula weight depending on the formula representation and rounding convention.
The ingredient is generally supplied as a white to light-yellow powder or crystalline solid. The actual appearance, moisture content, purity, and other properties should be confirmed against the technical data sheet and batch-specific certificate of analysis for the selected grade.
Commercial documentation describes Monoammonium Glycyrrhizinate as a solid material. It is hygroscopic in some grades, meaning that it can absorb moisture from the surrounding environment. Appropriate packaging and storage practices are therefore important for maintaining product quality.
Its solubility depends on the solvent and formulation conditions. Reference documentation describes solubility in ammonia water and limited solubility in certain other solvents. Product developers should consult the relevant technical documentation when selecting the ingredient for aqueous, emulsion, or other cosmetic systems.
Specific rotation and water content may be included in a supplier's specification. However, the applicable limits depend on the grade and the analytical method used. A result from one supplier should not automatically be adopted as the acceptance specification for another product.
Monoammonium Glycyrrhizinate is used in selected formulation systems for its ingredient functionality and compatibility with specific product designs. Potential application areas, subject to grade suitability and regulatory compliance, include:
The correct grade should be selected according to the intended application, purity requirements, solvent system, formulation pH, and local regulations. A research-grade material should not automatically be treated as suitable for commercial cosmetic or food use.
Quality assessment should confirm the chemical identity, CAS number, assay method, purity, moisture content, and batch traceability. Depending on the grade, a certificate of analysis may include HPLC purity, identification by infrared spectroscopy, specific rotation, and water content.
Different commercial grades may list minimum HPLC purity values, while some products use titration or other analytical methods. HPLC area percentage and titration-based assay results measure different things and should not be compared as if they were equivalent. The method and acceptance criterion should be recorded exactly as specified for the supplied grade.
Additional quality requirements may include limits for relevant impurities, residual solvents, and contaminants, where applicable to the manufacturing process and intended use. These limits should be obtained from the approved specification rather than assumed.
Monoammonium Glycyrrhizinate should be stored according to the product's approved technical data sheet and safety documentation. Some supplier guidance recommends cool, dark storage and protection from moisture. Keep the material in its specified, tightly closed packaging and follow any handling precautions supplied with the batch.
The storage temperature, shelf life, and packaging requirements should be confirmed for the exact commercial grade. Avoid assigning a universal shelf life without supporting documentation.
Before selecting Monoammonium Glycyrrhizinate for a formulation, buyers should verify:
For product enquiries, buyers should request the current grade details, technical data sheet, certificate of analysis, safety documentation, packaging information, and storage instructions from Swapnroop. These documents help establish whether the material meets the technical and regulatory requirements of the intended application.
All purity claims, numerical limits, and application statements should match the actual grade supplied. This ensures that the product page communicates the ingredient's identity and specifications accurately.
It is the monoammonium salt of glycyrrhizin, a constituent associated with licorice root. It is also called Glycyrrhizic Acid Monoammonium Salt or Ammonium Glycyrrhizate.
The commonly listed CAS number is 53956-04-0. Confirm the identity and any hydrate-specific designation against the supplied product documentation.
The commonly listed molecular formula is C₄₂H₆₅NO₁₆, with a molecular weight of approximately 839.97 g/mol.
Commercial specifications commonly describe it as a white to light-yellow powder or crystalline solid. The exact appearance is grade-dependent.
Commercial listings include grades with HPLC purity above 70% or 75%, among other specifications. The actual grade and assay method must be confirmed with the supplier.
No. HPLC area percentage and titration-based assay are different analytical measures. They should not be substituted for each other without an approved specification.
Review identity, purity or assay, appearance, water content, specific rotation where applicable, and any relevant impurity or residual-solvent limits.
Follow the approved product label and technical data sheet. Protect the material from moisture and follow the supplier's recommended temperature and light conditions.
| Parameter | Specification |
|---|---|
| Appearance | White to light-yellow powder or crystalline solid |