Mometasone Furoate Monohydrate is a synthetic corticosteroid active pharmaceutical ingredient (API) with potent anti-inflammatory and anti-allergic properties. It is the monohydrate form of mometasone furoate and is used in pharmaceutical formulations for conditions involving inflammation and allergic responses.
Mometasone furoate is a glucocorticoid corticosteroid that acts through glucocorticoid receptors to regulate inflammatory and immune responses. It is used in pharmaceutical products for applications including allergic rhinitis, asthma and certain inflammatory skin conditions.
Mometasone Furoate Monohydrate has the molecular formula C₂₇H₃₀Cl₂O₆·H₂O, molecular weight 539.45 g/mol, and CAS Number 141646-00-6.
Mometasone Furoate Monohydrate is a corticosteroid derivative containing a steroid nucleus with chlorine substituents and a furoate ester group. The monohydrate contains one molecule of water associated with each molecule of mometasone furoate. FDA's Global Substance Registration System identifies the monohydrate as a validated substance record and classifies it as a salt/solvate form.
The compound is particularly relevant to pharmaceutical development involving topical corticosteroid, intranasal corticosteroid and inhaled corticosteroid formulations.
Mometasone Furoate Monohydrate is used as the active corticosteroid ingredient in pharmaceutical formulations intended to manage inflammatory and allergic conditions.
Mometasone-containing pharmaceutical products are used in applications involving:
The precise indication depends on the pharmaceutical dosage form and regulatory approval in the relevant market.
Mometasone furoate is a glucocorticoid receptor agonist.
After entering target cells, corticosteroid molecules interact with intracellular glucocorticoid receptors. The resulting receptor complex influences gene transcription and regulates the production of inflammatory mediators.
This produces anti-inflammatory and anti-allergic effects, including reduction of inflammatory cell activity and mediator release.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Heavy Metals | NMT 20 ppm |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | 4.0% – 4.5% |