Moclobemide is a reversible inhibitor of monoamine oxidase-A (RIMA) and belongs to the benzamide class of pharmaceutical compounds. It increases the availability of monoamine neurotransmitters, including serotonin, norepinephrine and dopamine, by reversibly inhibiting their metabolism through monoamine oxidase-A. It is primarily associated with the treatment of major depressive disorder and depressive symptoms.
Moclobemide is a specialized central nervous system (CNS) pharmaceutical API used in the development and manufacture of antidepressant formulations.
Moclobemide is a synthetic pharmaceutical compound with applications in antidepressant and neuropsychiatric drug development. Its API quality assessment includes identity, assay, related substances, water content, residual solvents and other applicable pharmaceutical quality attributes.
CAS Number: 71320-77-9
Molecular Formula: C13H17ClN2O2
Molecular Weight: 268.74 g/mol
IUPAC Name: 4-chloro-N-(2-morpholin-4-ylethyl)benzamide
Drug Class: Reversible Monoamine Oxidase-A Inhibitor
Therapeutic Class: Antidepressant
Therapeutic Area: Psychiatry / CNS
Molecule Type: Synthetic Small Molecule
Moclobemide selectively and reversibly inhibits monoamine oxidase-A (MAO-A). MAO-A is involved in the metabolism of neurotransmitters such as serotonin, norepinephrine and dopamine.
By inhibiting MAO-A, moclobemide increases the availability of these monoamines in the central nervous system, supporting its antidepressant pharmacological activity.
Moclobemide API is associated with:
Moclobemide has been developed primarily for oral pharmaceutical formulations, including tablets.
Moclobemide is a solid crystalline compound. PubChem reports crystals obtained from isopropanol, with reported melting-point values of approximately 132–137 °C from referenced sources.
A controlled Moclobemide API manufacturing process may involve:
Moclobemide API quality evaluation may include:
Store Moclobemide API in a tightly closed pharmaceutical container under controlled storage conditions, protected from excessive moisture, heat and direct light.
Moclobemide is relevant to research involving:
Moclobemide is a reversible MAO-A inhibitor and antidepressant compound with CAS Number 71320-77-9, molecular formula C13H17ClN2O2, and molecular weight 268.74 g/mol. Its pharmacological activity is based on reversible inhibition of monoamine oxidase-A.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 0.50% |
| Residue on Ignition | NMT 0.1% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 4.5–6.5 |
| Individual Impurity | NMT 0.50% |
| Water Content | NMT 0.50% |