Mirodenafil, also known as SK-3530, is an orally active phosphodiesterase type 5 (PDE5) inhibitor. It inhibits PDE5, an enzyme involved in the degradation of cyclic guanosine monophosphate (cGMP), and is associated with the treatment of erectile dysfunction.
Mirodenafil is a synthetic small-molecule pharmaceutical compound belonging to the pyrrolopyrimidinone chemical class.
Mirodenafil is a specialized PDE5 inhibitor API used in pharmaceutical research and formulation development. Quality control should address identity, assay, related substances, residual solvents, water content and other applicable pharmaceutical parameters.
CAS Number: 862189-95-5
Molecular Formula: C26H37N5O5S
Molecular Weight: 531.67 g/mol
Synonyms: Mirodenafil, SK-3530, SK3530
Drug Class: PDE5 Inhibitor
Therapeutic Class: Erectile Dysfunction Treatment
Therapeutic Area: Urology / Sexual Health
Molecule Type: Synthetic Small Molecule
Stereochemistry: Achiral; no defined stereocenters
Mirodenafil selectively inhibits phosphodiesterase type 5 (PDE5). PDE5 inhibition increases intracellular cGMP signaling, which contributes to smooth-muscle relaxation and vasodilation under appropriate physiological conditions.
Mirodenafil is associated with:
Mirodenafil is also encountered as mirodenafil dihydrochloride, CAS 862189-96-6. Its molecular formula is C26H37N5O5S·2HCl and molecular weight is 604.59 g/mol. Commercial analytical material is reported with an assay of ≥98% by HPLC.
Mirodenafil free base has a molecular weight of 531.67 g/mol and is reported as achiral.
For the dihydrochloride form, commercial reference material is described as a powder/crystalline solid. Sigma-Aldrich reports ≥98% HPLC assay for its analytical material.
Typical Mirodenafil API testing may include:
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | NLT 98.0% by HPLC |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |