Milrinone Base is a synthetic bipyridine derivative and phosphodiesterase-3 (PDE-3) inhibitor. It increases intracellular cyclic adenosine monophosphate (cAMP) by inhibiting PDE-3, producing both positive inotropic and vasodilatory effects.
Milrinone is primarily associated with short-term cardiovascular therapy, particularly in settings involving acute heart failure and low cardiac output. The pharmaceutical injectable product is commonly supplied as milrinone lactate, while Milrinone Base is the active molecular form.
Milrinone Base is a specialized cardiovascular pharmaceutical API used in pharmaceutical development and manufacture. Important quality attributes include identity, assay, related substances, residual solvents, water content and other applicable pharmaceutical parameters.
CAS Number: 78415-72-2
Molecular Formula: C12H9N3O
Molecular Weight: 211.22 g/mol
IUPAC Name: 6-Methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile
Synonyms: Milrinone, Milrinone Base
Drug Class: Phosphodiesterase-3 Inhibitor
Therapeutic Class: Cardiovascular Agent / Inodilator
Therapeutic Area: Cardiology / Critical Care
PubChem confirms the formula C12H9N3O, molecular weight 211.22 g/mol, and CAS 78415-72-2.
Milrinone selectively inhibits phosphodiesterase type 3 (PDE-3). PDE-3 inhibition increases intracellular cAMP in cardiac and vascular smooth-muscle cells.
The resulting pharmacological effects include:
Milrinone is associated with:
Milrinone is primarily used in intravenous pharmaceutical formulations. Commercial injectable formulations commonly contain milrinone lactate, rather than the unmodified free base.
Milrinone Base is a crystalline pharmaceutical compound. PubChem reports a calculated molecular weight of 211.22 g/mol and an exact mass of 211.0746 Da.
A reported melting point for milrinone is approximately 315°C.
A controlled Milrinone Base API manufacturing process may involve:
Typical Milrinone Base API testing may include:
Store Milrinone Base API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Milrinone is relevant to research involving:
Milrinone Base is a PDE-3 inhibitor and cardiovascular inodilator with CAS Number 78415-72-2, molecular formula C12H9N3O, and molecular weight 211.22 g/mol. It increases intracellular cAMP and produces positive inotropic and vasodilatory effects.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 315°C |