Midodrine Hydrochloride is the hydrochloride salt of midodrine, an orally active alpha-1 adrenergic receptor agonist used as an active pharmaceutical ingredient in pharmaceutical formulations. It is primarily associated with the management of symptomatic orthostatic hypotension.
Midodrine HCl is a prodrug that is converted in the body to desglymidodrine, an active metabolite that produces vasoconstriction through stimulation of peripheral alpha-1 adrenergic receptors.
Midodrine Hydrochloride is a well-characterized cardiovascular pharmaceutical API used in the development and manufacture of oral formulations. Important quality attributes include identity, assay, related substances, water content, residual solvents and other parameters defined in the applicable API specification.
CAS Number: 3092-17-9
Molecular Formula: C12H20ClN3O2
Molecular Weight: 257.76 g/mol
Chemical Name: (RS)-2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide hydrochloride
Drug Class: Alpha-Adrenergic Agonist
Therapeutic Class: Vasopressor / Antihypotensive Agent
Therapeutic Area: Cardiovascular
Molecule Type: Synthetic Small Molecule
Midodrine HCl is converted to its active metabolite, desglymidodrine, which selectively stimulates peripheral alpha-1 adrenergic receptors.
This activity results in:
The active metabolite has limited penetration into the central nervous system, and its principal pharmacological effects occur through peripheral alpha-1 receptor activation.
Midodrine HCl API is used in pharmaceutical development related to:
Midodrine Hydrochloride is particularly relevant to formulations designed to increase blood pressure in patients experiencing symptomatic orthostatic hypotension.
Its active metabolite increases peripheral vascular resistance through alpha-1 adrenergic receptor stimulation, supporting its use in pharmaceutical development for blood-pressure management.
Midodrine Hydrochloride is generally described as a white to off-white crystalline powder or solid. It is characterized by its salt form, chemical purity and other physicochemical properties according to the applicable API specification.
Typical quality-control testing for Midodrine HCl API may include:
Midodrine HCl should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light. Final storage requirements should follow validated stability data and the approved API specification.
Midodrine HCl is relevant to research involving:
Midodrine HCl is a specialized pharmaceutical API suitable for qualified formulation development, pharmaceutical manufacturing and research applications. The material can be evaluated according to applicable customer specifications, validated analytical methods and relevant pharmaceutical quality requirements.
For Midodrine HCl API availability, technical documentation, specifications and commercial requirements, contact the API manufacturer.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |