Midecamycin is a macrolide antibiotic active pharmaceutical ingredient (API) used in pharmaceutical formulations and antibacterial drug development. It is a naturally derived macrolide compound with antibacterial activity against susceptible microorganisms.
Midecamycin inhibits bacterial protein synthesis by interacting with the 50S subunit of bacterial ribosomes, thereby interfering with the translation process required for bacterial growth.
Midecamycin is a specialized antibacterial API used in the development and manufacture of pharmaceutical formulations. Its quality is evaluated through pharmaceutical analytical testing, including identity, assay, related substances, water content and other applicable quality parameters.
CAS Number: 35457-80-8
Molecular Formula: C41H67NO15
Molecular Weight: 813.97 g/mol
Chemical Name: Midecamycin
Drug Class: Macrolide Antibiotic
Therapeutic Class: Antibacterial
Therapeutic Area: Infectious Diseases
Molecule Type: Natural Macrolide
Midecamycin acts primarily by binding to the 50S bacterial ribosomal subunit. This interaction interferes with bacterial protein synthesis and inhibits the growth and multiplication of susceptible bacteria.
Its antibacterial activity is associated with inhibition of the bacterial translation process.
Midecamycin API is relevant to:
Midecamycin has been used as a macrolide antibacterial agent against susceptible bacterial organisms. It is particularly relevant to research and formulation development involving respiratory and other bacterial infections where macrolide antibiotics may be considered.
Midecamycin is generally described as a white to off-white solid or powder. Its physical properties, including appearance, moisture content and solid-state characteristics, should be evaluated according to the applicable API specification.
Typical quality-control testing for Midecamycin API may include:
Midecamycin API should be stored in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light. Final storage conditions should follow validated stability data and the approved manufacturer's specification.
Midecamycin is relevant to research involving:
Swapproop Drugs and Pharmaceuticals supports the sourcing and supply of Midecamycin API for qualified pharmaceutical manufacturing, formulation development and research requirements.
Midecamycin can be evaluated according to applicable customer specifications, validated analytical methods and relevant pharmaceutical quality requirements. For Midecamycin API availability, technical documentation, specifications and commercial requirements, contact Swapproop Drugs and Pharmaceuticals.
Midecamycin is a macrolide antibacterial API with CAS Number 35457-80-8, molecular formula C41H67NO15, and molecular weight 813.97 g/mol. It acts primarily by inhibiting bacterial protein synthesis through interaction with the 50S ribosomal subunit.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |