Metoprolol Tartrate is the tartrate salt of metoprolol and a selective beta-1 adrenergic receptor antagonist (beta blocker). It is an established pharmaceutical active ingredient used in cardiovascular medicines. Metoprolol reduces beta-1 adrenergic activity in the heart, resulting in decreased heart rate and myocardial contractility.
Metoprolol Tartrate has the CAS Number 56392-17-7 and the molecular formula (C15H25NO3)2·C4H6O6, corresponding to a molecular weight of 684.81 g/mol. PubChem lists Metoprolol Tartrate as a salt consisting of two metoprolol molecules associated with one tartaric acid molecule.
Metoprolol Tartrate is widely relevant to pharmaceutical formulations intended for cardiovascular applications, including the management of hypertension, angina pectoris and certain cardiac conditions. The tartrate form is commonly associated with immediate-release metoprolol formulations.
Metoprolol Tartrate is used as an active pharmaceutical ingredient in formulations designed for cardiovascular therapy. Its pharmacological activity is primarily associated with selective blockade of beta-1 adrenergic receptors in cardiac tissue.
Swapproop Drugs and Pharmaceuticals provides pharmaceutical APIs for formulation development and manufacturing requirements. Metoprolol Tartrate API can be offered for customers requiring a reliable pharmaceutical raw material for cardiovascular formulations.
Quality parameters, analytical documentation and release specifications should be evaluated according to the applicable pharmacopoeial standard and the batch-specific Certificate of Analysis (CoA).
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 0.5% |
| Residue on Ignition | NMT 0.1% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 0.5% |
| Specific Rotation | +7.0° to +10.0° (αD20, after drying, C=2, H2O) |