Metopimazine is a phenothiazine-derived antiemetic active pharmaceutical ingredient (API) used primarily for the management of nausea and vomiting. It acts mainly as a dopamine D2 receptor antagonist and is associated with antiemetic activity. Metopimazine is also known by synonyms including EXP 999, EXP-999 and RP 9965.
Swapproop Drugs and Pharmaceuticals offers Metopimazine API for pharmaceutical development and manufacturing requirements. The API can be considered for applications requiring a reliable source of Metopimazine with appropriate quality documentation and batch-specific analytical specifications.
Metopimazine has the molecular formula C22H27N3O3S2 and a molecular weight of 445.60 g/mol. Its CAS Registry Number is 14008-44-7. The chemical name is 1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide.
Metopimazine is primarily associated with pharmaceutical formulations intended for the management of nausea and vomiting. It has been investigated and used as an antiemetic, including in settings involving chemotherapy-related emesis.
Swapproop Drugs and Pharmaceuticals focuses on supplying pharmaceutical APIs for formulation development and commercial manufacturing requirements. Metopimazine API is offered with product-specific quality documentation and analytical information to support pharmaceutical customers.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 168–170°C |