Metipranolol is a non-selective beta-adrenergic receptor blocker used primarily as an ophthalmic medicine for reducing intraocular pressure in glaucoma. It blocks both β1- and β2-adrenergic receptors and is classified as a beta-blocker.
Metipranolol is available as the active pharmaceutical ingredient and as Metipranolol Hydrochloride, the hydrochloride salt used in pharmaceutical preparations.
Metipranolol is a specialized ophthalmic and cardiovascular pharmaceutical API used in pharmaceutical formulation and research.
Quality control should address identity, assay, related substances, water content, residual solvents, elemental impurities and stereochemical characteristics according to the applicable pharmacopoeial or validated manufacturer specification.
CAS Number: 22664-55-7
Molecular Formula: C17H27NO4
Molecular Weight: 309.40 g/mol
Metipranolol Hydrochloride CAS: 36592-77-5
Metipranolol Hydrochloride Molecular Formula: C17H28ClNO4
Metipranolol Hydrochloride Molecular Weight: 345.87 g/mol
Drug Class: Non-selective Beta-Adrenergic Blocker
Therapeutic Class: Beta-Blocker / Antiglaucoma Agent
Therapeutic Area: Ophthalmology / Cardiovascular
Molecule Type: Synthetic Small Molecule
Stereochemistry: Racemic; 1 defined stereocenter
Metipranolol is a non-selective β-adrenergic receptor antagonist. By blocking β-adrenergic receptors, particularly in the eye, it reduces aqueous humor production and consequently lowers intraocular pressure.
Metipranolol is associated with:
Metipranolol hydrochloride has been used primarily in ophthalmic preparations, including eye drops and other topical ocular formulations.
Metipranolol is a solid pharmaceutical compound. The British Pharmacopoeia supplies metipranolol as a pharmaceutical reference standard.
A controlled Metipranolol API manufacturing process may involve:
Typical Metipranolol API testing may include:
Store Metipranolol API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Metipranolol is relevant to research involving:
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |