Methyprylon is a piperidinedione-class sedative-hypnotic compound that was historically used for the treatment of insomnia. It is also known by names including Metiprilon, Metiprilone, Noludar and Dimerin. NIST identifies Methyprylon with the molecular formula C10H17NO2, molecular weight 183.2475 g/mol, and CAS Number 125-64-4.
Methyprylon is a historical CNS depressant rather than a commonly marketed modern pharmaceutical. PubChem reports that it was withdrawn from the U.S. market in 1965 and from the Canadian market in 1990.
Methyprylon is a specialized CNS pharmaceutical compound relevant to pharmaceutical research, analytical reference applications and historical drug research. Its regulatory status should be assessed before commercial use in any specific market.
CAS Number: 125-64-4
Molecular Formula: C10H17NO2
Molecular Weight: 183.2475 g/mol
IUPAC Name: 3,3-Diethyl-5-methylpiperidine-2,4-dione
Synonyms: Metiprilon, Metiprilone, Noludar, Dimerin
Drug Class: Piperidinedione Sedative-Hypnotic
Therapeutic Area: CNS / Sleep Disorders
Molecule Type: Synthetic Small Molecule
These chemical identifiers are reported by NIST and PubChem.
Methyprylon is a central nervous system depressant. As a historical sedative-hypnotic, its pharmacological action reduces CNS activity and produces sedative and hypnotic effects.
Historically, Methyprylon was associated with:
NIST records Methyprylon as a solid. An evaluated infrared reference spectrum from the Coblentz Society reports a melting point of 74–77 °C.
A controlled Methyprylon API manufacturing process may involve:
Typical testing may include:
Store Methyprylon in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Methyprylon has significant historical regulatory considerations. PubChem identifies it as a DEA Schedule III controlled substance and notes its withdrawal from the U.S. and Canadian markets.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 2.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 2.0% |
| Water Content | NMT 2.0% |
| Melting Point | 74–77 °C |