Methylprednisolone Acetate is a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive properties. It is the acetate ester of methylprednisolone and is used in pharmaceutical formulations for managing inflammatory and immune-mediated conditions.
Methylprednisolone Acetate acts primarily through the glucocorticoid receptor, regulating gene transcription and suppressing the production of inflammatory mediators.
Methylprednisolone Acetate is a specialized corticosteroid pharmaceutical API used in the manufacture of injectable and other pharmaceutical formulations.
The USP monograph specifies NLT 97.0% and NMT 103.0% methylprednisolone acetate, calculated on the dried basis.
CAS Number: 53-36-1
Molecular Formula: C24H32O6
Molecular Weight: 416.51 g/mol
Chemical Name: Methylprednisolone Acetate
Synonyms: 6α-Methylprednisolone 21-acetate; Methylprednisolone 21-acetate
Drug Class: Glucocorticoid
Therapeutic Class: Corticosteroid / Anti-inflammatory
Therapeutic Area: Immunology / Rheumatology / Dermatology / Allergy
Molecule Type: Synthetic Steroidal Compound
PubChem lists CAS 53-36-1, molecular formula C24H32O6, and molecular weight 416.5 g/mol.
Methylprednisolone Acetate acts as a glucocorticoid receptor agonist. Following receptor activation, it influences gene expression involved in inflammatory and immune responses.
Its pharmacological effects include:
Methylprednisolone Acetate API is used in pharmaceutical development for conditions involving inflammation and immune responses, including:
Methylprednisolone Acetate is particularly associated with:
Methylprednisolone Acetate is a steroidal crystalline pharmaceutical substance. The exact appearance and physical characteristics should be controlled according to the applicable pharmacopoeial or approved API specification.
A controlled Methylprednisolone Acetate API manufacturing process may involve:
Typical Methylprednisolone Acetate API testing includes:
Store Methylprednisolone Acetate API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Methylprednisolone Acetate is relevant to research involving:
Methylprednisolone Acetate is a synthetic glucocorticoid corticosteroid with CAS Number 53-36-1, molecular formula C24H32O6, and molecular weight 416.51 g/mol. The current USP monograph defines its content as 97.0%–103.0% on the dried basis.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 97.0%–103.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 20 ppm |
| Water Content | NMT 1.0% |
| Melting Point | Approximately 224–230°C |