Methoxamine is a direct-acting alpha-adrenergic agonist and sympathomimetic compound used as a vasopressor. It produces peripheral vasoconstriction primarily through stimulation of alpha-1 adrenergic receptors, resulting in increased vascular resistance and elevation of blood pressure.
Methoxamine is mainly associated with cardiovascular and critical-care pharmaceutical applications, particularly the management of hypotension.
Methoxamine is a specialized vasopressor pharmaceutical API used in pharmaceutical research and formulation development. The hydrochloride salt, Methoxamine Hydrochloride, has been used in injectable pharmaceutical preparations.
CAS Number: 390-28-3
Molecular Formula: C11H17NO3
Molecular Weight: 211.26 g/mol
IUPAC Name: 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Synonyms: Methoxamin, Methoxamedrine, Pseudomethoxamine
Drug Class: Sympathomimetic / Alpha-Adrenergic Agonist
Therapeutic Class: Vasopressor / Antihypotensive Agent
Therapeutic Area: Cardiovascular / Critical Care
Molecule Type: Synthetic Small Molecule
Methoxamine acts directly on alpha-adrenergic receptors, with selectivity for the alpha-1 receptor subtype. Its stimulation of peripheral alpha receptors causes vasoconstriction and increases systemic vascular resistance.
Methoxamine is associated with:
Methoxamine Hydrochloride has historically been supplied as an injectable solution, including preparations containing 10 mg/mL or 20 mg/mL.
Methoxamine free base has the molecular formula C11H17NO3 and molecular weight 211.26 g/mol.
The hydrochloride salt is reported as colorless or white plate-like crystals / white crystalline powder, with a reported melting point of 212–216 °C.
Typical Methoxamine API testing may include:
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Individual Impurity | NMT 0.5% |
| Total Impurities | NMT 1.0% |
| Water Content | NMT 1.0% |