Methdilazine is a first-generation antihistamine belonging to the phenothiazine class. It possesses antihistaminic and anticholinergic properties and has been used primarily for the relief of itching associated with various dermatological conditions. PubChem identifies methdilazine as a histamine antagonist, cholinergic antagonist and antipruritic compound.
Methdilazine is a synthetic pharmaceutical compound relevant to antihistamine, dermatology and pharmaceutical research.
Methdilazine is a specialized antihistamine API used in pharmaceutical development and formulation. Quality evaluation should include identity, assay, related substances, residual solvents, water content and other applicable pharmaceutical quality parameters.
CAS Number: 1982-37-2
Molecular Formula: C18H20N2S
Molecular Weight: 296.43 g/mol
IUPAC Name: 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine
Drug Class: First-Generation Antihistamine
Chemical Class: Phenothiazine
Therapeutic Class: Antihistamine / Antipruritic
Therapeutic Area: Dermatology / Allergy
Molecule Type: Synthetic Small Molecule
The CAS number, molecular formula and molecular weight are confirmed by NIST and the Royal Society of Chemistry's Merck Index.
Methdilazine acts primarily as a histamine H1 receptor antagonist, reducing the effects of histamine involved in allergic reactions and itching.
It also possesses anticholinergic activity, which contributes to its broader pharmacological effects.
Methdilazine is associated with:
Methdilazine has historically been used in oral pharmaceutical preparations, including tablets and other formulations depending on the applicable market.
Methdilazine is described as a crystalline solid.
A controlled Methdilazine API manufacturing process may involve:
Typical testing may include:
Store Methdilazine API in a tightly closed container under controlled pharmaceutical storage conditions, protected from excessive moisture, heat and direct light.
Methdilazine is relevant to research involving:
Methdilazine is a phenothiazine-class first-generation antihistamine with anticholinergic properties. It has CAS Number 1982-37-2, molecular formula C18H20N2S, and molecular weight 296.43 g/mol.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder or crystals |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.5% |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
| Water Content | NMT 1.0% |